In the case of Wexner, Leslie Wexner does talk about being possessed by a Dybbuk.

They are drawn when in that lowered state. When their conscious mind and spirit has been removed from the controls to be nothing more than an avatar driven by a force that desires to burn down churches and rape children.

Medical issues. In this case, it's not a medical issue. It's a spiritual issue. They are demonically infested. That's no joke. It's not an exaggeration. There are actual demon or demonic entities that are possessing these people. And then what happens is the body, the physical body, begins to mirror the internal dark spirit structure.