Boulware found that there was no benefit to taking the drug, but Kirsch didn't accept the results and the interpretation of the research, and things fell apart from there. As the pandemic has gone on, he's shifted from promoting infective drugs to being convinced that everyone's trying to conspire against these ineffective drugs that he's decided are effective, like hydroxychloroquine and ivermectin. And this is predictably spiraled out of control into basically a strong anti-vax position.