Jon Beckwith, Harvard geneticist born December 25th, 1935, debunks claims of synthetic life creation as hype while warning about ethical misuse—like insurers exploiting genetic data or flawed predictions of criminality. He critiques the government’s smallpox vaccination push and past biological warfare experiments (e.g., Fort Dietrich), stressing that "junk DNA" (90% of the human genome) remains poorly understood despite rapid sequencing advances. Beckwith also highlights risks of distributed computing projects like Genome@Home, where probabilistic disease data could spark misguided decisions, and dismisses fringe theories like human de-evolution or 900-year lifespans. Ultimately, his work underscores science’s moral obligations amid accelerating research and public misinformation. [Automatically generated summary]
From the hot desert of the great American Southwest, I bid you all good evening, good afternoon, good morning, whatever time this may be, wherever you are in all of those time zones out there, I'm Mark Bell, and this is Coast to Coast AM.
How you all doing?
I'm going to tell you right up front, it's been a very difficult week in the Bell household.
Ramona, my wife, beautiful wife, has had a really serious asthma attack over the last week, and so I've been kind of playing household person, and as a result, my back, she's better now, she's better, but my back, from the point in the bus, my back is kind of beginning of some spasms, so we'll see how it goes tonight.
It should be, assuming that I can hang in their very, very interesting program.
Professor John Beckwith is scheduled to be here.
And the reason he's scheduled to be here is because of that story that I just kept harping and harping and harping on, because I think it is so important.
You know that story about scientists creating life?
One more time, Ed, for you and then for the professor, scientists in Rockville are to announce this morning, this was now November 21st, that they plan to create a new form of life in a laboratory dish, a project that raises ethical and safety issues, but also promises to illustrate the fundamental mechanics of living organisms.
J. Craig Vetter, the gene scientist with a history of pulling off very unlikely successes, successes, and Hamilton O. Smith, a Nobel laureate, are behind the plan.
Tonight's guest probably will know these people.
Their intent is to create a single-celled, partially man-made organism with the minimum number of genes necessary to sustain life.
If the experiment works, the microscopic man-made cell will begin feeding and dividing to create a population of cells unlike any previously known to exist, i.e.
we are creating life.
To ensure safety, Smith inventor said the cells will be deliberately hobbled.
Remember this story now, to render it incapable of infecting people?
It will also be strictly confined and designed to die if it does manage to escape into the environment.
Well, tonight's guest is a Harvard man who was at the absolute zenith of genetic research and had himself a lot of breakthroughs at the beginning of all this and now has reservations about where it might all be going.
Professor Beckwith.
And so I think it's going to be a very, very interesting program.
By the way, here's an interesting little did scientists have decoded the genome of the mouse using human stem cells.
That's controversial in itself.
Using human stem cells, it is now possible to create male mice that produce human sperm.
Think about that.
Male mice that can produce human sperm and female mice which carry human eggs.
Breeding these mice will produce offspring too horrible to even contemplate.
Our boy, we really are taking a giant leap into a brave new world.
That's what we're going to talk about in the next hour.
This hour, let me browse through a little news since I haven't had a chance to catch up with you on what's going on in the world.
Oh, by the way, on the web, oh, the website, we've got a very interesting photograph that was sent to me by Ray in Ojai, California.
And it's an older photograph, but you know, it's of a UFO 80 feet off the ground.
And this gentleman came across a photo in an estate auction.
Now, it seems like an awfully clear photograph of a UFO.
People always complain, gee, they're always, you know, fogged up and kind of blurry.
And, well, this one's pretty sharp, folks.
You might want to take a look at artbell.com up tonight as of now.
that's one item.
Another item would be this man who...
I really don't know how to explain what I'm seeing unless it's a hoax or unless the laws of physics have recently gone through some change that I'm not aware of.
At any rate, both here in the U.S. and now in Germany, he sent these photographs from Germany.
This man puts ice in his freezer, but the ice jumps up to reveal these I mean, short of anti-gravity, somebody would have to explain to me how water could ever in a trillion years do this on its own.
So either it's a hoax or something weird surrounds this man or the laws of physics have been modified in some way that I'm not aware of.
Anyway, you might want to see the photographs of some of this ice in his freezer.
It's really, really weird stuff.
Don't ask me.
Go take a look.
It's all at artbell.com.
And again, I'll remind you that upon my retirement December 31st, the website's going away forever, and there is an opportunity for you to get a copy of the website.
It's out on CD, actually.
And it's one hell of an offer, and that offer ends at the gong of the present year ending.
So if you want to know about that, go to my website, and that offer ends then.
Boom, Over.
So you need to take advantage of it now.
I will sign some of those CDs.
Keith Rowland has now agreed.
Remember, I mentioned that?
He'll have agreed to sign some of them as well.
And I think deservedly so.
He has along with me through the years, I think we were actually the originators of the combination of websites with radio or radio with websites, however you want to look at it.
And obviously, the things we talk about here are kind of strange.
And a lot of times, visual aids, when they're available, particularly for things like ghosts and UFOs and all the sorts of things we've talked about over the years here, it's been simply invaluable to the program as far as I'm concerned.
And I want to thank Keith for all the years he's put in in sticking with me every minute through the program.
At any rate, since the website is going down, and there will be a new one for the ongoing program with George, and a very nice one, I'm told.
This one will be history, a little piece of history that you can have on a CD.
The United States, after stopping a ship and finding Scud missiles on their way to Yemen, is now deciding that they're going to let Yemen have the missiles.
They were on the way from North Korea to Yemen, and we stopped, well, the Spanish stopped the ship.
We got on board.
We found the Scud missiles, and I guess there was a whole lot of diplomatic crosstalk that went on, pulling and tugging.
And in the end, the U.S. has decided to allow them to continue on to Yemen.
Now, how many of you think those Scud missiles were really for Yemeni's defense?
Or do you think those missiles were going to go on toward Iraq?
Pretty good question, I'm sure one that we're asking or we're asking, but somehow we've decided to let them go so Scud missiles go to Yemen.
North Korea, Yemen, we intercept and then we say, oops, well, Yemenis want them, so, you know, they sell us oil too, right?
Intelligence agencies that were supposed to protect Americans from the September 11th hijackers failed to do so because they were poorly organized, poorly equipped, and slow to pursue clues that just might have prevented the whole thing from happening, according to lawmakers on Wednesday as they completed their investigation into the attacks.
U.S. troops are going to get shots, smallpox vaccinations.
It's all going to be voluntary.
Some emergency workers and troops are going to, if they want them.
Now, see, I'm not so sure.
Over the years, I've interviewed a lot of people about vaccinations.
So I'm thinking, you know, if I was still in the Air Force, for example, would I volunteer to take a smallpox vaccination?
Well, let's see.
On the one hand, the danger of vaccinations in general.
On the other hand, possible death due to smallpox.
I don't know.
I might.
The U.S., as you know, is taking a declaration provided to the U.N. by the Iraqis, what, 12,000 pages or something about whether or not or what they've got, what the Iraqis have.
I'm sure that as they look over that declaration, it'll say, yes, we have four atomic bombs located at the following locations in the desert.
Just go to the little X past the cactus.
You can dig them up.
And yes, we have biological weapons capable of killing millions at the following locations.
I mean, come on, folks.
What do you think their declaration is...
My God, they had forever.
I mean, those things are going to be so far underground that one of our bunker busters probably couldn't get to them.
But you know they're there, and yet we go through, we're going through this little political weird dance with the U.N. and the rest of the world having them go in and inspect.
My God, they were long gone.
If they are there, certainly they're long gone.
Unnormally stoic and silent during such arguments, our Supreme Court, in the person of Justice Clarence Thomas, found his voice unusually on Wednesday condemning crossburning as a symbol of oppression, 100 years of lynching in the South by the Klukbucks Klan.
So this is the second time in a decade that they've had this kind of case, and we'll have to see where it goes.
The Reverend Paul Shanley, a central figure in the clergy sex abuse scandal, was jeered by angry protesters Wednesday as he left a courthouse free on $300,000 cash bail.
You know, this whole thing with the church, not this specific case, because of course it's court-bound and we'll have to see what happens, but the whole thing with the Catholic Church and what they're going through right now is horrendous.
And I'm sure it is challenging some people's ability to remain within the church.
Now, it would be tough, wouldn't it?
I'm not Catholic, but if you were Catholic, my wife certainly is, watching what's happening with the church now and these incredible number of molestation cases is just about too much.
The U.S. reminded Iraq and other countries.
Now, this is a Reuters story you might not have heard or seen.
The U.S. reminded Iraq and other countries on Tuesday that we are prepared to use nuclear weapons should it become necessary to respond to an attack from any country with weapons of mass destruction.
So we're saying throw something at us, anything that's massively destructive, and we will, well, you can expect a mushroom cloud over one of your cities or something on that order.
And so I think it's well we remind the world that we do have the largest stockpile of nuclear weapons.
And if somebody tries to kill hundreds of thousands or millions of us, we will use them.
And we will turn your country into glass.
So think really hard before you release anything.
I am in agreement with that policy.
The northernmost reaches of the earth are warming, reducing the sea ice across the Arctic Ocean, melting the ice sheet in Greenland, and spreading shrubs into the Alaskan tundra.
This is an Associated Press story.
Taken individually, the changes only suggest the region's climate is undergoing a warming trend.
Together, they provide dramatic evidence the change is real.
This is all according to a panel of scientists and their report at a meeting of the American Geophysical Union.
If you look at all the data sets together, they do provide compelling evidence something is changing over a great area, according to Larry Hisman, University of Alaska at Fairbanks, where they see these changes going on.
Natural variability may be behind the changes, but human activity might also be to blame.
A new five-year research plan presented this week by scientists and government officials meeting in Washington, D.C., asserts that people clearly are agents of environmental change.
You hear that?
People are clearly agents of environmental change, though it is still unclear how much human activity contributes.
So they are no longer wondering whether man's hand is having an effect in our environmental changes.
No longer wondering, they're sure.
It's just they don't know how much.
A new five-year research plan presented this week by scientists and government officials meeting in Washington, D.C., asserts people are clearly agents of environmental change, and the president wants industry to voluntarily cut back smokestack and tailpipe emissions of carbon dioxide and other heat-trapping gases.
Evidence of the rise can be seen across the Arctic already.
Greenland experiencing a warm spell unseen since the 1930s.
Satellite data shows the greatest area of melts is across a mammoth ice sheet.
In 24 years of measurement, that ice sheet has melted more this year than any other.
Since 1979, the melt area has grown by 16%, is now affecting higher and higher elevations.
So if you were wondering whether the change is real or all this is absolute bunk, the answer is the change is real.
And I'm going to say what I've said for a long time.
We should stop arguing about whether our climate is changing and begin taking steps to adapt to that change so that our economy doesn't crash and burn, so that we can continue to provide food for the people of our country and others who depend on us.
For a variety of very important reasons, the politicians ought to get off the controversial, is it or is it not happening?
Because baby, it's happening.
And they should get on to the more practical aspect of, what do we do about it?
One more brief story.
New observations by a NASA spacecraft orbiting Mars show a planet rich in water, but now suggest that for billions of years it has done little more than remain frozen within the soil.
The finding challenges theories that Mars was once a warm, wet place, hospitable to life.
Instead, the current Martian surface, a cold, dusty, overwhelmingly dry place, may have been the norm for much of the planet's history.
We thought, right, that it was warm, wet, all the rest of it, and something came along, a big rock out of nowhere and destroyed the Martian atmosphere.
Maybe not.
They're suggesting, yes, there is water everywhere on Mars, all over the place, but it's in the soil, it's below the ground, perhaps as little as 18 inches below the ground.
So there's a lot of water.
Now they all confirm what Richard C. Hoagland said a long time ago.
Yep, a lot of water everywhere on Mars.
But they're saying, we don't really think that there was once an atmosphere with Martians running around and life happily adapting and progressing on Mars.
And then kaboom.
We rather think now it has been billions of years.
And Mars has been in essentially the condition we find it in right now.
Kind of interesting.
It challenges a lot of the more recent theories that Mars did have an atmosphere.
Maybe not.
Maybe it's always been that way.
At least, always as far as we're concerned, billions and billions of years.
I'm Art Bell.
And of course, in the middle of the night, you're listening to Coast to Coast AM.
Open lines coming right up.
unidentified
Well, I think it's time to get ready To realize just what I have found I have been all in care of what I am It's all clear to me now My heart is on fire My soul's like a wheel
that's turning My love is alive Where are those happy days?
They seem so hard to find I tried to wait for you But you have close to mine Whatever happened to our love I wish I'd find you this thing It used to be so nice It used to be so good But when you're near me, darling Can you hear me?
It's all it The love you gave me now It used to be so nice When you're gone How can I even try to go on?
When you're gone Go and die How can I carry on?
Art Bell in the Kingdom of Nye from west of the Rockies at 1-800-618-8255 East of the Rockies 1-800-825-5033 First-time callers may rechart at 1-775-727-1222 and the wildcard line is open at 1-775-727-1295 to rechart on the toll-free international line call your AT ⁇ T operator and have them dial 800-893-0903.
A pact would allow U.S. troops into Canada during an emergency.
U.S. troops could find themselves on Canadian territory helping police and firefighters deal with emergencies under a new pact signed by both countries.
Listen to this.
The new accord says soldiers from either country, either country could cross a border, but would then be under the command of the host country.
Defense Minister John McCullum said the pact recognizes that threats such as those posed by terrorists or perhaps biological weapons don't recognize international borders and continues a long tradition of Canada-U.S.
cooperation in dealing with common threats.
So one way or the other, either Canadian troops here or American troops there, if conditions would warrant.
Yeah, but how does that fact that war does occur in cycles, I think we all recognize it has for all of human history, how does that suggest that you don't protect yourself?
Listen, if somebody attacks us with a biological agent that kills millions, a chemical agent that causes many to die horribly, or, God forbid, with a nuclear weapon, then skaroo them, and the proper response is to light them up, melt them.
And I'll tell you something else.
History proves with regard to cycle, sir.
It proves that those who are weak and do not protect themselves, I'm not talking about going adventuring in a war here.
I'm talking about protection.
You know, like it's provided for in the Second Amendment individually.
If somebody comes into your house going to harm you or your family try to kill you, you have the right to shoot them first.
The Same thing goes for countries.
If somebody wants to demolish our country and they attack us with some sort of weapon of mass destruction, then I think we should melt them.
I'm trying to put it as bluntly as I can to you, but melt them.
End of story, period.
Now, whether it comes in cycles and can or cannot be predicted or is tied into sun cycles or the way a mouse runs across the floor, I don't care.
It's called protecting yourself and those you love.
There's something that is so obvious that the scientists may not be recognizing if they create a form of life which they think has all the protection features that if it gets out of the environment, that it'll self-destruct, that it can reproduce, et cetera, et cetera, the thing that looks like it's obvious that they're missing is the chance for mutation.
And mutation, we know, can generate another new form naturally, a new form of life which may not have the exact same characteristics which they intended to start out with.
It struggles and clings to life, whether it's us, you know, human beings we're talking about, or microorganisms.
And if clinging to life means that it must amorph into something else, that's exactly what it will do.
That's how it all works.
You change or you die.
And so you're right.
This new life will probably try to cling to what we give it, and then God knows what might occur.
I think we're stepping off onto a very slippery slope.
unidentified
Yes, indeed.
I agree with you wholeheartedly that there should be perhaps even these scientists should be put into question before they continue their work and try to finish it up.
There's a lot, sir, of what science has done in recent years that I really think the public has a right not only to know about, but in essence to debate.
And, you know, these are such big questions.
The wrong move, and we all could die.
And so why not let everybody know what they're going to do and we could all judge the relative merits of going ahead?
But I think the creation of life, you know, the god-like creation of life is no small matter.
It's a big thing, and it's, you know, really a big thing.
unidentified
Yeah, all they're concerned about is making the breakthroughs.
They think they're carrying out science to another level.
In the meantime, they probably haven't figured out all the ramifications of what they're doing.
That's basically what we're going to be talking about tonight with somebody who has been there, done that.
You know, much like the scientists who created the nuclear bomb, many of them had second thoughts.
And when they realized the consequences of their creation, they changed.
And many of them petitioned presidents not to go forward, not to drop the bomb, not to continue research into this area like we ever really stop anything.
So, yeah, this whole thing makes me very nervous, and that's why the professor is going to be on tonight.
In fact, about a week ago, they chased unknown contrails.
They saw contrails moving from the Caribbean out across the U.S. mainland, and they scrambled jets and chased those.
There are many other reports of U.S. planes chasing UFOs.
Many reports.
So the answer is a lot of times we do know about it.
I think the real answer is the military just doesn't like to admit, for the most part, anything they can't do anything about.
unidentified
That could very well be true.
I was at D-Day, Normandy, Southern France, Iwo Jima, and Okinawa on an unrelated note, and I saw the rise and fall of Adolf Hitler, and the world leaders would be wise to recognize that in the antics of Saddam Hussein, this is how Adolf Hitler got his start, and he must be stopped at any cost.
I mean, we have very short lives relatively, but our memories within those lives are also short, and we tend to forget things like the rise of the Third Reich and Adolf Hitler.
And so, yes, indeed, Saddam Hussein fits right into that, perhaps into that same category.
Not only have I seen the jets that you're talking about, but we have had, over the last week or so here in Perrump, Nevada, a constant stream of black, odd-looking, unmarked helicopters going directly over the house here and really weird stuff, just jets all over.
The United States is getting ready to go to war.
That's what's going on.
unidentified
I wondered if that was, because they were flying like two came so close together, it looked close from where you are on the ground, and like the chemtrails just like absolutely just like went together.
And they were just flying.
I saw so many of them just flying back and forth, back and forth, like in a grid pattern, but a straight grid pattern, and just laying down these trails.
And they just all of a sudden just appear, and you'd see the lines and the chemtrails, and they'd just keep coming.
We know to some degree, or even a great degree, what they've got in Iraq.
We know they've got the willingness to use it.
And I rather think that we are preparing for the inevitable.
Again, why we're doing this dance with the UN and the rest of the world, I suppose I understand it to some degree politically, but we might as well just get ready to end.
We are getting ready to do business, so that's what you're seeing in our skies.
And I've talked to you a number of times from Montreal, which is where I'm from.
When I was a younger guy, back in the 60s, the States was all involved in Vietnam, and we Canadians were very friendly towards the U.S., but we thought, what are you guys doing in that dumb, dumb war?
And I'm really glad that you pulled out of it and got out of it, because it was a dumb, dumb war.
Now I'm in my 50s, and I'm way more conservative than I was back then.
And I'm watching what's happening out in the Middle East, and I'm, you know, just nauseated.
And I completely agree with what you said a few minutes ago.
Anybody who takes on the U.S., yeah, use what you got.
Turn them to the glass.
I'm completely behind you on all of that.
And I'm very, very pleased, actually, that our two governments, Canada and the U.S., have now signed a deal for UELPOS to go help you.
And it wouldn't bother me a bit if the border came down between the two countries because the world's getting real small.
We have this huge continent to look after, to protect, and defend.
Yeah, I would find it a little strange to look down the corner and see a Canadian Maple Leaf guy there, but whatever would have to be so that we might survive, so be it.
My recollection of the last time that we had a war with Iraq was that President Bush at the time, Dad, said that we would stop for humanitarian reasons.
Remember that?
It was going so well, and we had so few casualties, and then we decided to stop, just like that.
And I've never fully understood nor appreciated why we would stop for humanitarian reasons.
I mean, here we are having to go back and in essence, finish the job.
And the humanity I would like to consider first is right here in this country.
When you have a war, W-A-R, the big war word, then you kill and you break things.
That's what our military does.
And so if we're facing our own possible extinction, then I say let us kill and break things.
I know.
Very hawk-like, isn't it?
But how else do you protect your country, your loved ones, all that we stand for?
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called "Las Cache." "Las Cache." This is the Spanish version by a group called "Las Cache." This is the Spanish version by a group called "Las Cache." This is the Spanish version by a group called "Las Cache." This is the Spanish version by a group called "Las Cache." This is the Spanish version by a group called "Las Cache." This is the Spanish version by "Las Cache." This is the Spanish version by "Las Cache." This is the Spanish version by "Las Cache." This is the Spanish version by "Las Cache." This is the Spanish version by "Las Cache." This is the Spanish version by "Las Cache." This is the Spanish version by "Las Cache." This is the Spanish version by "Las Cache." This is the Spanish version by "Las Cache."
Rechart bells in the Kingdom of Nye.
From west of the Rockies, dial 1-800-618-8255.
East of the Rockies, 1-800-825-5033.
First-time callers may rechart at 1-775-727-1222.
Or use the wildcard line at 1-775-727-1295.
To rechart on the toll-free international line, call your AT ⁇ T operator and have them dial 800-893-0903.
This is Coast to Coast AM with Art Bell on the Premier Radio Networks.
I've been receiving emails all night long tonight.
This one comes from somebody who read the book.
Hi, Art.
I just finished reading the novelization of the upcoming Steven Spielberg miniseries, Taken, actually underway right now, that's airing on the SyFy channel.
Guess what?
You're in it.
The name of the radio host is William Jeffries.
But it's definitely you.
I won't spoil it for you, blah, blah, blah.
Thank you very much, Sean, in Seattle, Washington.
But I've had all these...
And I think it was said that a very great deal of what you hear on that program is true.
So thank you, Steven Spielberg.
Thank you very much.
Coming up in a moment, Professor John Beckwith.
He was born December 25th, 1935, in Cambridge, Massachusetts.
He received his college and graduate Ph.D. degrees in chemistry and biochemistry at Harvard University.
In graduate school, he became interested in genetics and thereafter spent five years of postdoctoral work in labs in the U.S., England, and France.
He took an assistant professorship at Harvard Medical School in 1965, has been there ever since, teaching and heading a research group.
Right on the edge, folks, he is now an American Cancer Society professor in the microbiology department.
He has always worked as a geneticist studying the bacteria E. coli, rather common inhabitant of the human gut.
He has studied such problems as how cells which are surrounded by a membrane are able to secrete some proteins across their membranes, how proteins that are made up of sequences of amino acids fold into their final structures, how cells manage to grow and eventually divide into two cells.
In 1969, his lab was the first to find a way to isolate a pure gene from an organism.
This is very important.
While he was proud of his achievement, he was also worried that this accomplishment was an indication of how quickly we might be approaching the possibility of not only bacterial DNA, but also human DNA, human genes, and manipulating them.
He called a press conference to announce the achievement and at the same time to issue a warning that we had better start thinking about the consequences of the ability of scientists to manipulate genes.
This press conference had the consequence of initiating Beckwith's lifelong involvement in promoting social responsibility in science and working to prevent the potential abuses or misuses of genetics.
He was involved, for example, in controversies around the claim that males with an extra Y chromosome were doomed to live lives of criminality.
He was also critical of other genetic theories that claim that our lives are largely determined by our genes.
In 1989, he was appointed to the working group on the ethical, legal, and social implications of the human genome project of the National Institutes of Health.
He worked to anticipate any potential harmful consequences of the human genome sequence for the public and promote programs, laws, and so forth that would prevent these problems from occurring.
Professor John Beckworth is a member of the National Academy of Sciences and received the Genetics Society of America Medal in 1993, both for his scientific achievements and for his social activism.
It will be closer in August to the Earth than it has been in 50,000 years.
And this will give you an opportunity, if you have a really good telescope, to see Mars as you will never again see it in your lifetime.
And boy, do we have a really good telescope?
Christmas!
Well, it's right around the corner.
And I can't think of any better gift for you and your family than a really good deep space telescope.
This baby is gigantic.
It's the newest one we've got.
It comes on a tripod with equatorial mount.
You will see, and it's a little more expensive than the one that we had before, and that's because it's bigger and better.
It's $439 plus shipping and handling, but Harden Optical is dedicated to getting deep space telescopes, really good ones, to people at a reasonable price in America so that you all can do a little looking.
Who knows?
You might find something coming around the bend toward us.
Anyway, once you've spent a little time looking through the eyepiece of a telescope, your worldview will change.
That's no small matter.
Now you can go see it at forthenightsky.com.
That's F-O-R-ThenightSky.com.
Or you can call to order, have it there for your Christmas tree, not that it will fit under, at 1-800-394-3307.
That's 1-800-394-3307.
Now, imagine feeling 10 years younger in 10 weeks.
You cannot, of course, because nobody ever has until human growth hormone, HGH.
Now, this is not the injectable sort that I'm sure you've seen on magazine shows because there have been many reports about it.
It actually does move you toward youth.
It seems to arrest the aging process and move you toward youth.
Now, they've got synthetic HGH that I'm sure you've seen that's injected into the stomach.
No, thank you, not for me.
And ultimate HGH that we've got that causes your own body to make more of your own safe HGH.
The results are spectacular.
Beginning at about six months, you will have physical documentable changes in your body.
Stronger bones, mood elevation.
You'll have a better cholesterol profile.
You can measure that.
A 14.4% loss of fat on average with no dieting.
An 8.8% increase in your muscle mass on average.
No exercising.
All of these things are a sharper vision.
You can go to the eye doctor and you'll find out your eyes are now going the other way.
They're becoming sharper.
And so many other things that we associate with youth.
I call it younger and younger.
It's about $33 a month if you'd like to try it.
That compares quite favorably with any competitive product anywhere.
It comes from, naturally, Great American Products.
And their number, if you'd like to try this and you've got to stick with it for about six months to see those physical changes, so do that, is 1-800-557-4627.
That's 1-800-557-4627.
Professor Beckwith, I am honored to have you join me this evening.
I want to read you a story, and I'll get to that in a moment.
You've been then for all of your adult life, your professional life, in the world of genetic research, study, and I guess the ethical aspects of all of this.
Well, that's a danger of prediction in science, that there are often breakthroughs that make things happen much faster than one expects.
And that's where one has to be particularly concerned about the social and ethical consequences of research, because you can't assume that things aren't going to happen.
Yeah, it was basically that people develop better and better approaches to doing it, and the technical, the development of better and better computer programs for interpreting the data, et cetera, just helped it move very, very quickly.
I'm not frightened easily, but I want to read you this story.
It comes from the Washington Post, Thursday, November 21st, and this one hit me squarely between the eyes.
Here it is: Scientists at Rockville are to announce this morning, that date, that they plan to create a new form of life in a laboratory dish, a project that raises ethical and safety issues, but also promises to illustrate the fundamental mechanics of living organisms.
J. Craig Ventner, the gene scientist with a history of pulling off unlikely successes, and Hamilton O. Smith, a Nobel laureate, are behind the plan.
Their intent is to create a single-celled, partially man-made organism with the minimum number of genes necessary to sustain life.
If the experiment works, the microscopic man-made cell will begin feeding and dividing to create a population of cells unlike any previously known to exist.
To ensure safety, Smith Inventor said the cell will be deliberately hobbled, interesting word, to render it incapable of infecting people.
It will also be strictly confined and designed, in fact, to die if it does manage to escape into the environment.
More worrisome than the risk of escape, they acknowledge, is that the project could lay the scientific groundwork for a new generation of biological weapons, a risk that may force them to be selective about publishing technical details.
But they said the project could also help advance the nation's ability to detect and counter existing biological weapons.
Put another way, Professor, they are creating life, are they not?
Particularly the picking up on biological weapons.
Clearly, they're trying to latch on to the current concern in the country and then rouse interest in their project.
I think one interesting thing is Venter, who was one of the two, head of one of the two groups that did decipher the human genome, once they had the genome information, he called a press conference and said the amazing, maybe amazing statement, and I'll paraphrase because there's one word in there I don't want to use exactly, but he said, we really don't know SQAT.
Even though we have all this information, in a sense, we really don't know what we're doing because we still have a lot to learn.
Gee, that builds a lot of confidence in me personally.
this story actually scared me for, you know, a number of reasons.
One is, they say it would be...
And somehow it finds a way not to die, gets loose and finds a way not to die.
You know, life sort of clings to life, doesn't it?
And so who knows?
It might, as one caller said in the last hour, it might change so that it doesn't respond to being hobbled and die quickly when it hits the atmosphere out of the petri dish or something awful.
I mean, it just seems we're taking leaps that we perhaps ought not be taking, or at least not without public debate of some sort.
There are a lot of issues where I think we need public debate over whether and how to proceed, or at least with what kind of cautions to proceed with this kind of research.
However, in a sense, we've been doing this, creating new organisms all the time since the beginning of the field of genetics.
We've isolated mutants, combined mutants, made new organisms that have different properties.
We've made fruit flies that grow wings out of their eyes, all sorts of interesting organisms.
But the other issue is that a fly that has wings growing out of its eyes is not a very successful organism.
It's got a lot of problems and does not survive very well.
So I think there's a little bit of, I'll call it hubris or pride that the scientists have to imagine that they can create something that will be as successful as nature has created.
I don't think there are really any good examples of that so far.
When you had your breakthrough, Professor, I wonder if there was a moment in time when, no doubt, like a lot of the scientists who were working on the atomic bomb, once they understood what they had created, many had second thoughts, many had very reflective moments about what they had just done.
It must have been kind of a moment like that for you, was it?
And also, I was very much influenced by that experience because I was in high school in the late 40s and early 50s and then went to college.
And it was shortly after World War II when atomic weapons had been used.
And I was very aware of scientists like the most famous of them, I think, being J. Robert Oppenheimer and also Einstein at some point, were very upset about what had been done with their science, even though they might have anticipated.
And it just made me feel that one should really anticipate and think ahead and try to understand where we're going with scientific developments and make sure that they benefit people and aren't used in destructive ways.
Was there ever a flash of a moment when you thought, you know, perhaps I ought not release this information because I'm beginning to see clearly where it could lead?
It didn't happen at that point, although I have to say, one of my colleagues on the project quit science, although he eventually returned saying exactly what you're saying, that he didn't want to contribute anymore in a way that might lead to dangers in the future.
And I have to say, through the 1970s, as other techniques, better techniques than our own became available to pull out genes from organisms, including humans, I really, for several years, felt that I did not want to participate in this research and made public statements to that effect.
Yeah, well, I mean, they've already done things, for instance, like alter mice so that they produce antibodies that are really basically human antibodies and that might be useful for treatment of disease.
And I think for the most part, I don't know about the eggs and sperm story, but for the most part, the orientation of the people who are doing it is for medical purposes.
And I'm not a scientist, but is it not possible that in the process of doing that, you might not get exactly what you wish to get, and what you might get is some horrid little combination of, let's say, some virus that a mouse has always carried, and it has never had anything to do with human beings until we got in there with our genetic shovel.
And then all of a sudden we've got some sort of combination mouse-human thing that now jumps quite happily to human beings and isn't good at all.
I think that's a constant problem with these advances, that people perhaps innocently trying to advance medical knowledge and medical techniques are doing things, sometimes driven by money, which becomes a problem, that have potential dangers.
I think one of the examples is moving too quickly with what's known as gene therapy, where you try to cure people with genetic diseases by introducing new genes into their chromosomes.
And we've had a lot of problems with that.
Some people have died.
Some people have got other diseases as a result of those approaches.
And the question is, should you be cautious to the point where you wait until you're absolutely sure that that's not going to happen and you just proceed.
I certainly agree that there should be public debate.
But I also think that one of the problems with our scientific education is that we focus entirely on the science.
I never got anything in any way in my education telling me that one should also worry about the consequences of science, that science has tremendous benefits for society, but there also can be problems.
And there's this long history which we will repeat unless we as scientists are educated to understand that this is something we have to be concerned about.
With your knowledge, the knowledge you have, Professor, of genetics, if you wanted to, would you be able to create, for example, a biological weapon that would target, oh, I don't know, a certain race, for example.
And it would kill people of one race and not another?
I would say, first of all, that it's not a thought that has escaped some military researchers in the past, and I've seen articles suggesting that this is a possible direction that research might take.
The problem is that when you look at what are called races and look at their genes, they're really not very much different than the genes from other groups that are defined as races, white race, black race, yellow race, whatever.
To a greater extent, but it still represents only a fraction of that population.
So if you designed a weapon that would somehow target individuals carrying a particular gene that was more prevalent in one group, what you'd find is that it would affect some fraction of that group, probably not a large enough fraction to be of any military value.
And at the same time, it would attack a fraction, although a smaller fraction, of your own group.
And that's because basically we're really all one species.
Our honored guest is Professor John Beckliff, a Harvard professor who has made genetic breakthroughs himself, very serious ones.
And that's what we're talking about where all of this is going.
It's the little things, folks.
You might want to stick around and listen.
We were discussing, just going into the bottom of the hour, the possibility that some weapon might be developed that would essentially be a suicidal device or organism.
And so I want to follow up on that a little bit.
Professor, do you believe that it would be technically either is technically possible now or will be within a few short years to create, in effect, a biological doomsday organism, something that, if released, would virtually be doomsday.
I mean, would race around the earth like a wildfire, killing as it went.
Would such a technical feature is it either possible now or will it be?
I'm somewhat skeptical about that possibility in that I think one can probably develop, for example, super virulent bacteria that might for a short space of time have some really destructive effects.
But I think, in fact, we have, or countries have, maybe Iraq has weapons right now that are known organisms that are not genetically engineered that are perfectly capable of wreaking as much havoc as they might want to wreak.
Well, ones that are very much in the news, like Bacillus anthracis, the organism that causes anthrax, causes anthrax, and we certainly know about from what happened earlier within the last year in this country.
And in the wrong hands and with the right delivery system, that can be incredibly destructive, and there's not too much that could be done about it.
Nevertheless, I think one can generate organisms that are destructive, but I think nature has selected organisms to be as destructive as they want them to be, and ones that are genetically engineered, I think, may be able to wreak some havoc, but I don't think they're going to last very long.
In other words, like a wildfire, they would burn themselves out very quickly, and there wouldn't be any way to biologically engineer them to be more persistent.
Well, I ask this because the world has now proven to us again and again that we have lots of people out there and organizations willing to commit suicide to cause mass death.
I mean, you see it in Israel almost every day.
So if there should be such a thing, I don't think there would be any shortage of hands willing to release it.
Going back for a second, you mentioned the anthrax mess that we had right after 9-11.
There's been an ongoing investigation in this country which now has become suspiciously quiet, in my opinion, as to where this anthrax may have come from.
Have you been contacted by anybody in that regard?
Yeah, they actually told me, a group actually told me After the particular controversy was over, that they had been meeting to consider going to the dean of the medical school to have me removed from tenure because of my criticism of a study there.
This was over a program that was going on in a hospital in Boston, connected with Harvard Medical School, where they were screening newborn baby boys to see whether they carried an extra Y chromosome.
And this was, at the time, considered among at least some scientists to be an indication, that is the extra Y chromosome of a baby, male baby that we grow up to have super aggressive tendencies and perhaps criminal tendencies.
And there were a lot of dangers associated with that study, and we tried to raise it in terms of the ethical propriety of doing this kind of screening and what the impact on the young boys would be, particularly when if you looked at the science behind it, the previous studies, they were really extremely weak and at that point were not considered likely to be true.
Well, what happened was that the parents, the newborn baby boys would be screened, then the researchers would go to the parents and say, we want to study your kids, and the parents would generally find out that their children were XYY males.
And since there had been so much publicity about the XYY male as supercriminals, it caused enormous anxiety for the parents.
And potentially, and I spoke to actually one of the parents called me up when our criticisms were made public and supported what I said.
It said that she said that they had been so worried about their child that any little move the child made that seemed a little bit off, they would react to with the child.
And so the researchers were intervening in this family life in such a way as to perhaps cause downstream lots of problems for the children and the way the parents were raising the children.
And this is where I wanted to follow up on your question about the problems I ran into.
In those days, to raise the kinds of questions we did were considered sort of almost like betraying my role as a scientist.
But now that that kind of information is becoming much more available than it was then, scientists are worried that it will have some consequences and that if anything bad happens to people because of their genes that they're screened for, that it will redound back to science and hurt scientists themselves.
How many years away, Professor, are we, for example, from the ability to say, you know, this baby has a very high likelihood of having a stroke or a heart attack or contracting cancer prior to, say, age 40.
That statistically we can now say that's probably going to happen to this child.
Now, I ask that because that child just might have a really hard time going to get life insurance or even health insurance.
But I just wanted to make that point clear, that nothing is predetermined.
And if somebody is screened and found to carry a particular altered gene, you can talk about risks and probabilities.
And quite often we can't be very accurate about that even.
But the information can be misused or at least used, if you want to call it misused, to prevent people from getting insurance, or it's been used in deciding on employment in some cases and in various other realms of society.
I think we already can screen for a fairly large number of genetic conditions, and in particular for susceptibility to heart attacks at an early age.
For some of the people who have that problem, we can actually detect that now.
The availability of the human genome sequence that came out a few years ago is just picking up the pace of that development very rapidly.
And one of the interesting things is when the Human Genome Project started, there was at least enough awareness among scientists at the time that this kind of problem was going to arise that they did start a program to look into the ethical and social and legal consequences of having all this information.
Not that we've solved it, not that we've come up with ways of controlling it, but some things have happened that have added some protection to people.
So if a genetic testing van rolls into Prump, Nevada, and I have the opportunity to go down and find out if I have a propensity for this or that or whatever in a free test, should I jump right on it and take the test, or should I avoid it like the plague?
I think if you can take the test, you should take it if there is some reason to think that they, first of all, that the information would be useful to you.
But in addition, I think one should look very carefully into what kind of privacy is associated with that information.
Well, yeah, but therein lies a big problem because a lot of times when you're assured privacy regarding a matter, for example, all the people got tested for AIDS and that sort of thing, and then somehow it just doesn't work out, dog on it, and the list or whatever it is gets out.
Well, an awful lot of physical diseases, there are just increasing number of them, that we can now offer some suggestion as to what the likelihood that people will suffer from them.
It has been claimed that soon we'll understand also the genetics of things like intelligence or behavior or sexual orientation or whatever.
I think that's at best much further off.
And what has been one of the big disappointments for the genome researchers is that it has been extremely difficult to find genes associated with human behaviors.
What differentiates people in terms of their aptitudes or their behavior or even things like mental illness, which involves brain functioning.
And researchers are realizing that these conditions are much more complex, probably involving many genes, which makes it very difficult to predict if many genes are involved, and also the strong influence of the environment.
Yeah, I think we will find genes that contribute to these behaviors, but I still think the problem of predictability becomes even more severe in those cases where some particular trait of yours is due to a combination of many genes interacting with each other and interacting with the environment.
Nevertheless, if it were discovered that a certain combination will, in fact, with a high degree of probability, predict criminal behavior, there would be, or even worse yet, something society really can't tolerate, pedophilia or something like that, then is it not going to be irresistible for society to act on that information?
Well, certainly if you had that, that would be the case.
My own impression is, from what I know of this field, that the proportion of people where that predictability would be so strong as to warrant intervention is going to be a small fraction.
That's not to say it would not be helpful to have that information, but I think it's going to represent a small fraction of the population of criminals, for instance.
I guess genetic information, if I understand correctly, it could come from underneath your fingernail or it could come from a scraping of skin or it could come.
I think it's all well and good for me to talk about we're aware of the problems.
We're trying to do something about them, but the pace of progress is incredibly fast.
And to deal with them and to set up the laws or the privacy regulations that will control it is difficult.
And, for example, a lot of interesting research could be done with knowing the genomes of a large proportion of the population in terms of finding disease genes, et cetera.
But at the same time, you have to worry about the privacy of that information.
So research, there's a sort of tension going on between people who are concerned about privacy and researchers who would like to see the research move as fast as possible.
And I hope that the privacy side of it wins out.
When I say the difficulties for researchers pursuing this research, it means much more care taken computer encoded files, et cetera, that can't be broken into and all kinds of expensive equipment and maybe tedious approaches to collecting this information that researchers are not too happy with because they would like to move as fast as possible.
Is it possible for our military, through people in science like yourself, to research defenses against biological warfare without developing biological warfare?
Yeah, but I think, as I said earlier, that a lot of those things have already been done in that we already have the organisms that are the weapons of choice of the moment for doing this kind of biological warfare research.
Yes, but in researching the latest, greatest, and who knows where they are now.
I mean, I'm sure you have a sense perhaps of where they are now, but they're probably way ahead of whatever they're publicly admitting to at the moment.
And so when they say they're researching all these biological defenses and so forth, I always think, you're right, and stuff.
Yes, our guest is, honored guest is Professor John Beckwith from Harvard, and we're talking about genetics and really the state of the world right now.
In the moment, we'll talk for a second about smallpox.
All right, as recently as the newscast this hour, Professor, we're hearing that the United States is beginning to give vaccine shots to the U.S. military for smallpox, smallpox vaccine shots, and that health workers, I guess, also can voluntarily decide to take it or not.
There's a lot of arguments about vaccines in general.
And I guess if you were in the military, Professor, and they offered you a smallpox vaccine shot, would you take it?
I mean, first of all, I'm not certain of the worth of it at this point in terms of the dangers, but also embedded in the dangers of some kind of smallpox biological warfare attack.
And at the other end of it, you know, there are some small fraction of people who take that vaccine who are going to perhaps die or certainly suffer some physical consequences from it that could be fairly serious.
It's kind of a risk-benefit kind of ratio.
And I knew the history of smallpox is that once it had been effectively eliminated as a disease in the world, there was a big debate as to whether one should destroy all stocks of the virus, the smallpox virus, because of the potential that it ever got out again or it got into the wrong hands, that it could be terribly dangerous.
And interestingly, the former chairman of my department, who was a wonderful person and a very socially conscious scientist, was one of the people who argued for maintaining that stock because someday we might need it to develop better treatments for it.
It could be in a reservoir, some animal reservoir, or someplace that we hadn't really expected.
I really can't repeat the reasoning.
But now in retrospect, the question arises again, should we have agreed to an international treaty to destroy all stocks of smallpox, which didn't happen?
I know one of the things people are worried about is that, particularly since the Russians hold or did hold stocks, whether, given the condition of that country, whether the smallpox has got out to other sources now.
But we certainly don't, at least as far as I know, we don't know for sure that that's happened.
Well, you know, I was thinking, I mean, it costs a lot of money to produce all this vaccine that they're producing and to then distribute it and all the rest of what they're doing right now.
And why would they do that if they don't know something?
Or even to, if they present themselves as knowing something that in fact might reflect other motivations.
I mean, it seems to me we're in a war readiness mood in this country, and the government is trying to promote that to some extent.
And I'm not sure whether the fear factor doesn't come into this to help to rally the people behind the government to indicate how many threats there are to us, and we really have to do something about it.
I mean, do you really think we would do this without some, I don't misuse the word intelligence, but without some intelligence to indicate there's a real threat, would we really begin vaccinating people?
And then they were going to drop a nuclear weapon.
Quarterized the whole thing.
I wonder if something like that is actually somewhere deeply perhaps five levels under the White House, you know, in a library somewhere as a plan that we might have to take.
I mean, if you were scientifically consulted and you were facing some sort of horrible organism and asked for your opinion on what best to do in a situation like that.
Now, I've been reading stories to my audience recently about this Italian doctor who claims that he has successfully cloned and has a pregnant woman in the Middle East somewhere who's going to give birth in the spring.
And then there's his partner, scientific partner, or ex-scientific partner, I guess they had a falling out of some sort, who said, you know, he's full of it, but we are on the edge.
We're about to clone human clone.
We're going to have a human clone.
So a lot of competition going on out there right now.
And it seems like if we don't already have one in the cooker, it's on the horizon pretty soon.
Well, I think we've certainly cloned animals that, you know, are getting, in terms of species, getting closer and closer to humans, so that technically it seems that those kinds of experiments ultimately will be, if you want to call them experiments, their cloning procedures could potentially be carried out in humans.
And something I learned back when we first isolated the gene was never to say, oh, that can't be done or it's so far off we shouldn't worry about it.
Because as we talked about earlier in terms of the DNA sequencing, things can move much faster than expected.
Nevertheless, I think there are some severe technical problems, at least at the moment for the foreseeable future with the qualification I've offered, to doing cloning and what the consequences will be.
Not that the things that were done in sheep couldn't be done in humans, but that the product may have serious problems.
And a lot of scientists from studies they've done have raised this issue, that as opposed to something like in vitro fertilization where a human sperm and a human egg are put together and the egg is fertilized in a test tube and reimplanted, here you're doing something very unnatural.
You're taking a cell, removing its DNA, putting in the DNA from another cell, and then hoping that it will develop properly.
And it's clear from the sheep cloning and it's clear from many other studies that you may be creating a lot of problems for that individual that you've cloned.
It may be born and it may grow up and even behave and physically be very normal for a while, but you may create some real downstream problems for that individual.
I've heard some Liz talk that Dolly the sheep, though young, may in fact be very old because the genetic age of the real parent is cared forth somehow or another, mistakenly, to poor Dolly, who is now like an 80-year-old sheep, even though Dolly's young.
Yeah, I haven't particularly heard that, Although that's certainly a major concern about it, I've heard about various problems with various cloning experiments.
I believe in the case of Dolly that they've noticed obesity and unusual obesity in the sheep that have been cloned.
So, and that could be related to what you were just suggesting.
It's not clear.
But it's exactly the sort of problem that people are worried about.
And as opposed to many other things, in this case, I think there's a lot of even scientific opposition to proceeding this, and that's for technical reasons.
Now, of course, there are other things to be concerned about as to whether as a society or as a species we want to go ahead and start cloning ourselves.
I mean, yeah, I think that's a significant possibility or probability.
And that's what makes the whole area so strange.
I mean, even if one accepted the idea that cloning was morally and ethically acceptable, in order to find out what to do cloning, you have to do experiments that I think are morally and ethically unacceptable because you may be creating monsters or individuals who really have severe deformities or serious problems as a result of the cloning.
Well, of course, I'm sure the scientists would terminate any such, in quotes, monsters very early, but there would be a lot of people who would say, gee whiz, ethically and morally, I have a big problem with that because you're creating and destroying life in the name of science.
When in vitro fertilization was first done with a fertilized, with women who had, couples who had fertility problems, when they fertilized sperm outside of the womb in the test tube, fertilized with sperm of the egg for the woman, there was a lot of societal opposition to it at the time.
And what stunned me is how rapidly that became an accepted procedure.
People, once they got used to the idea, somehow accepted it.
I don't know whether the same thing will happen if cloning ever really is successful.
No, not at all.
I think there are lots of and I don't want to stop at the technical problems and say, well, I think it's bad because you may be creating people with severe problems either right away or downstream in their lives.
I think there are also problems with it because the individuals who would be going ahead with it and doing it are doing it because they anticipate that they are creating somebody in the image of someone else and that that individual would basically have all the same qualities and characteristics of the individual whose DNA was used to clone the individual from.
And that is extremely unlikely, in fact.
And the concern about bringing an individual into the world whom is loaded with the baggage of having all these expectations of whatever the person who chose to do the cloning lays on them, I think is a serious burden for a child to grow up with.
So I think that it could create all sorts of psychological problems and all sorts of disappointments in the people who are doing the cloning when the clone doesn't live up to expectations.
But in the real world, it's not going to stop it because, I mean, there's enough egotistical people in the world with more money than they know what to do with who are going to pay somebody who, you know, there's always somebody with their hand out who wants to do the scientific work anyway.
And so, you know, somewhere around the world, they're probably doing it right now.
Yeah, I mean, if it's happening in a very small scale in a few places, it's not something I'm not happy with it, but it's not something I'd worry about.
And in fact, as you may know, I think in Europe cloning, which is a much stronger feeling about that is the whole United Europe now has its much stronger feeling about genetic issues.
There is a strong, I believe, a ban against cloning.
But as you said, there are countries where there is no such ban and it could be a problem.
I mean, I think ultimately the other thing that people worry about, which I hope isn't a worry, and I sort of doubt that in this day and age it won't happen, is that at a political level, governments might decide to create clones for their own purposes.
And both for technical reasons and for other reasons, I think that would be a failure, but I think it would also be a very frightening thing to happen.
But I guess I'm optimistic enough to think that the world is becoming a smaller and smaller place in certain ways in terms of interactions between different countries, that those kinds of things won't happen.
You mean if a country, for example, could develop the perfect soldier, stronger, more violent, in every way, a perfect killing machine, you don't think they would do that?
I don't think they do it, and I don't think it could be done anyway.
Because I think earlier when I talked about the predictability of genetics, I think there's a mistaken feeling, certainly among many in the public, that we can predict and we can know what a person is going to develop into just from looking at their genes, and that's simply not the case.
I get these little messages called Fast Blast as we do the show on my computer, and here's a pretty good one from Bruce in Clovis, New Mexico, who says, Art, your guest answer about genetic targeting of races not really being feasible seems to be at variance with the observation he quoted somebody else that we don't know squad about the human genome.
Yeah, I worried about making that statement because I didn't follow it up with what I meant.
First of all, what happened when the Human Genome Project was started, in order to raise money for it, the scientists who were doing it said, once we have the sequence of the human genome, we will know what it means to be human and all sorts of promises about all the cures for disease that would come out of it.
But of course, the human genome sequence was just the beginning.
It didn't tell you much of anything.
I mean, it told you some things, but it really didn't give you the information you needed.
It required much more research.
And immediately, when the genome with sequence was completed, people like Venter realized that if they kept saying that they knew everything now, then why should they be funded anymore for doing research?
So they came up with, I mean, and they're right.
I mean, in that sense, we haven't learned that much from the genome.
We are learning more and more as we begin to study it, but we don't know that much.
But certain things we did know from comparing the genome of, and one of the levels at which we did know something and really have been able to find out a lot, is by looking at the DNA sequences, the genome chromosome sequences of different groups of people, that people are much more similar than would be expected if there were really significant differences in races.
And in some senses, we've known that all along.
But for instance, one of the pieces of information which violates the We Don't Know SQAT statement is that we've been able to find out much more about human migrations throughout history by looking at the DNAs of different people in different places and seeing which genes were carried to which regions, et cetera.
And again, it's not that you look at pure populations that all carry one set of genes and that distinguish them from other populations, but that certain genes are more frequent in one population than another.
Harvard professor, Dr. John Beckwith, is my guest.
We're talking about genetics because that's where his research is.
And he's got some reservations about some areas of this research, and for very good reasons, I think.
But he's one of the men who made the original discoveries.
We'll be right back.
Once again, Professor Beckwith, Professor, would it be possible to create perhaps a clone, a human being, that was brain challenged?
In other words, through genetic manipulation, could you create a human that essentially was a vegetable but otherwise progressed along just fine, bringing with it these wonderful collection of organs that would be so suitable for transplant if you needed them?
Well, I mean, if you had a lot of money and you were 85 years old and your heart and your lungs were failing, and, gee, there was this shiny new pair that were a perfect genetic match for you, that sort of transplant would be would have a high degree of success probability, wouldn't it?
I mean, I would not be active around these issues if I didn't have some Optimism and hope that as a species we will ultimately arrive at the right, and we may go through some problems, but that we'll arrive at the right answers to many of these problems.
Well, there's this public service announcement for organ donation that it's kind of interesting.
It has this fellow lying there, apparently dying of something or another.
And they come to him and they tell him, well, you know, by golly, we just, you know, got a new liver in or whatever it was he was about to die from not having.
And he said, oh, wonderful, let's go.
And they say, oh, and by the way, it's from a Hispanic man.
And then he says, no, well, then you're going to die.
And, well, okay, then let's go.
So you cling to life and you do at the end whatever you have to do.
And if you've got the money, I suppose why you would, you know, do this.
And I think, you know, the cloning, there are people who would love to be cloned.
And I guess there are doctors who are claiming that they're doing it now.
But whether that, first of all, becomes a widespread practice is questionable.
And secondly, whether as societies approach these problems, and certainly they're discussing them in at least many of the societies of the world, there's international bioethics groups that are discussing them.
They may just discuss and discuss and nothing may happen, but it's not as though nothing is being done to confront these issues.
Something similar to cloning apparently has already been done.
Years ago in Southern California, there was an entrepreneur who collected sperm from Nobel Prize winners, and then for Pricewye offered to fertilize women with the money, with the sperm, so they could have really bright children.
Now, is there basic underlying common sense to that?
Would it work or have a good probability of working?
And I would love to know what became of those children.
One never hears anything about them.
Did it work?
And do they still do this?
And do they advertise great success rates, et cetera, and what do the success rates mean?
You know, it is quite conceivable that if a woman bears a child by this process whom she knows carries genes from a Nobel Prize winner, that the way she deals with the child may help ensure that that child develops super skills, et cetera.
Or it may be, again, a problem of expectations that if she expects too much from the child, the child may develop problems.
I've never seen a study that followed up on any of these children, so I have no idea whether the, let's call it, experiment worked or not.
And we have no basis at the present time for knowing that it will work.
One can worry about the safety issues, etc., but the very creation itself, I'm not sure.
I mean, we move along in time, and things that seem strange and maybe some things we shouldn't do at some point later on, we have different ideas.
I talked already about in vitro fertilization, where people were saying exactly the same thing about that, that that's, you know, it's unreal, it's not the normal means of procreation, we shouldn't be doing it.
And somehow we've come to accept it.
And I'm not saying that we should accept everything, but I think, and I think cloning is a case where one can have serious reservations about pursuing that line.
But in this case, particularly, it's not humans we're talking about anyway.
It's the kind of smallest of possible bacteria that probably, in fact, can't survive very well on their own.
I mean, through genetics or some aspect of genetics, you would think that cancer would be probably the number one positive development to come from the unraveling of the genome and then going a little further and understanding the combinations.
You would think cancer would be right there at the head of the list.
Well, one of the problems is that cancer is a vast array of different diseases with different causes.
One can find certain cancers, for example, that are known to be caused by mutations in genes that people inherit.
One can find other cancers that occur because either because of exposure to environmental pollutants or just the natural processes, one accumulates mutations in one's cells and cancer develops.
And these mutations can be in many, many different genes and cause very different kinds of cancers in very different places.
So what has happened over the years is that a certain number of cancers have been at least treatable or people are able to survive them pretty well by various procedures, including surgery, but also by various treatments.
But we're dealing with multiple diseases, and our success Rate at curing a large number of diseases is still very limited.
And partly, I think what has come out of the human genome is a humbling recognition of how complex we are and how complex many diseases and many human traits are.
And that it's not going to be as simple as people thought when they started this project.
I mean, it has been, I would say, a disappointment for scientists to recognize the complexity of human life.
I mean, I think there have been some interesting successes.
There are certainly not cures, but there are treatments for AIDS with this multiple drug use, which really is, to me, one of the best examples.
Although I've raised many problems about genetics, it's one of the best examples of how sort of the rapid progress in knowledge has allowed one to develop drugs that one couldn't have imagined, say, 20 years ago or so, that one couldn't imagine ways of developing them.
But it has led the quality of life for people who've developed the disease that are now, as you know, are able to live much longer and have a higher quality of life.
I think the concept behind that perhaps flippant statement is, though, that when we can manipulate genetics to the degree that we could change our eye color with a shot or something, then we will be in the business of manipulation to the level necessary to attack AIDS or cancer or something.
I mean, there are different approaches to dealing with AIDS.
One of them is vaccines, and basically that's been a failure so far.
That doesn't mean it's always going to be a failure.
There may be some new breakthrough in understanding how you make vaccines, how antibodies are made, that will suddenly open up prospects that we couldn't imagine before.
Well, they really, actually a friend of mine has published a book on the history of prions.
It's called, well, it's being used French, but it's been translated to English.
It's called something like Why Cows Go Mad, which has to do with the prion disease in cows, the mad cow disease.
And the history of this disease goes way, way back in terms of animals suffering from this disease.
And in fact, the human version of it has been known also.
But I think what we're finding is as the world gets more and more crowded that diseases that were rare in the past, for various reasons, are spreading much faster and occurring more frequently.
But it's certainly always been with us.
Why it's picking up now may have to do with the way animals are raised, for instance, which is very different from the way they used to be raised.
But it did exist.
As I said, my friend traces it reports of the animal disease back many centuries.
When we look at the human genome and we look at human evolution, is there any way to understand how the genetic structure of human beings may have been modified along the way?
Or is there any way to sort of look back, as you would, with a test to determine the age of something, some sort of scientific test?
In other words, do we have any idea whether we've always had the same genetic structure since day one for human beings?
Or can you look back and say, aha, see how it's changed over the thousands of years or whatever?
I think basically one can say we've had the same genetic structure.
I think what one can learn as one accumulates information about genomes of other organisms, I think you mentioned that the mouse genome was just released within the last week, I think.
As you get genomes of organisms, apes, monkeys, et cetera, that are closer to humans, I think you'll be able to see more and more what took place that actually resulted in changes that led to the very particular nature of human beings and human understanding and communication and culture.
Well, as I said earlier, I don't want to say something's never going to be possible, but I think we're talking about way off in the future if it is possible.
I guess I can imagine anything is possible in the long run, but that could be a thousand years from now if we're still around, which I have some questions about.
I frequently interview some pretty brilliant theoretical physicists who have the same reservations about our being around for a particularly long period of time and think the odds are not exactly in our favor.
Well, my major concern is environmental changes and whether we're ever going to get those under control.
I would say that's the first thing I think of.
I mean, along with issues of war and disease, we've already talked about the increasing spread of a number of diseases because of the changes in the world.
And we're not dealing with some of these problems in the way that I think we should.
So I worry about it.
I have children and grandchildren, and I do worry about it.
I also have been reading to my audience story after story recently about, oh boy, we're now starting to get some organisms that appear to be immune to our last sillin of defense.
So that would indicate to me that while we were winning for a while, you know, a very short while actually, in the larger scheme of things, that the little things seem to be getting a lead on us here.
That has been a problem that many of us have been aware of for many decades, that the increasing resistance of bacteria to the antibiotics that exist.
And for a while there, we were able to come up with new ones, but that's not happening anymore, and it's a serious problem.
There are a lot of people researchers making efforts to discover new antibiotics, but I know even some of the drug companies have kind of given up on it because it's involved a lot of money spent on research that so far hasn't paid off.
That's again, you know, not just a research problem or a scientific problem.
It's also a problem of enormous overuse of antibiotics throughout the world, both in feeds of animals, but also not only in this country, but even more so maybe in other countries where a lot of antibiotics are sold over the counter.
Well, when they finally failed, Professor, then perhaps genetic manipulation will be the only defense we'll have left, or the one that we can look forward to as saving our butts?
I guess that's a possibility in that for any bacterial infection, there are some people who are going to be more resistant than others to that infection.
It doesn't make it a genetic disease.
It's simply that there's some fraction of the population that's resistant.
There's an interesting argument, I don't know if you followed this at all, that the plague, which killed off a lot of people in Europe, uses some of the same receptors as AIDS virus.
And in some communities where a large percentage of the population died off, those communities not only were the people apparently in those families resistant to the plague, but today are resistant to AIDS virus.
There's quite a bit of scientific evidence to indicate that a number of prostitutes in Africa who just mystically have not come down with the AIDS virus and should have times 100 simply have not because they've developed some sort of immunity.
Professor, hold on, we're at the top of the hour.
It goes very quickly when the information flows this fast.
We'll take a break and be right back.
Harvard Professor John Beckwith is my guest.
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I mean, there are lots of ways in which you can do prenatal screening or in vitro fertilization and even screen the fertilized eggs to see if there are any particular genetic characteristics that you don't want.
Not so much characteristics you do want because the positive ones are harder to screen, but to some extent that may be coming.
But the amount of information coming out of the Human Genome Project's successes is spectacular in terms of being able to identify genetic mutations that are responsible for a whole range of different kinds of genetic diseases.
Well, speaking of genetic mutations, what's your feeling with regard to the environment as it is right now, probably being responsible for genetic mutations?
I mean, you alluded to your concern for the environment.
I certainly have it, too.
There are some pretty weird things going on and changes going on.
I mean, soon there won't be any...
They say we're going to have a new sea.
Well, I mean, these are big changes, and you would think that they would perhaps produce genetic changes if they are produced that way.
Well, we're still speaking from a bit of, not a bit, but a lot of ignorance about exactly what the effect in the environment is.
But we do know, for example, that as the ozone layer has decreased, that more people are being exposed to more ultraviolet radiation, which itself is well known to cause mutations.
What the actual increase in frequency of mutations might be and what its consequences are, we simply don't know.
We also know that there are certain kinds of chemicals and radiations and other kinds of radiation that cause mutations, and they're well documented in terms of particularly workers who've worked with radioactive materials or have worked in chemical factories where they're particularly strong exposure to chemicals.
It's pretty hard to come up with figures on exactly how much of mutation is due to environmental exposure because mutation is something that occurs naturally.
It's the fuel of evolution, in fact.
So in that sense, if you consider the fact that we're here is due to the fact that mutations occurred, then mutation was certainly a good thing.
I certainly think so, and that's been an issue for quite a while.
It led, of course, all sorts of regulations in industry in terms of exposure, etc.
But as I said, we're still a bit ignorant about, for example, how serious an effect pollution has on mutation rates.
We don't know.
There were surprising results, in fact, that after looking for mutational effects of the dropping of atomic bombs in Japan in World War II, where some scientists at least reported that it wasn't as severe as people might have thought.
That's just to illustrate our lack of knowledge, partly because it hasn't been studied in enough detail.
You know, just for fun, I potted up the newscast this last hour.
I don't know whether you were listening on the phone or not, but call me cynical and suspicious.
But gee whiz, they had the first lady on there saying, well, first of all, they said they're going to now provide, I guess, enough smallpox vaccine for everybody in the country.
And the first lady was on the radio saying, I wouldn't even hesitate to have my children vaccinated for smallpox.
And, you know, I guess I'm a little suspicious here that they really do know something.
I mean, vaccinating the entire nation, that just seems like an expensive, risky thing to be undergoing unless you've got real hard information about a possible problem.
I have to keep harboring my suspicions about ulterior motives, et cetera.
So I think certainly the president wants to mobilize support for whatever is going to happen in the near future militarily.
And I think part of the support is convincing people of the seriousness of the threat.
Now, the problem is we aren't provided with any of that information, as we're not provided any information as the government has on exactly what it is that Iraq has.
I think it would be nice to, I'm sure there are reasons they're not giving it to us, but there's been enough deception in the past that at least I keep an open mind about these questions.
So I tend to be skeptical about the need for the vaccination, but I could be wrong.
I just, you know, I mean, you look at what they do more than what they say, and what they're doing seems awfully out of proportion to the risk, as you sort of outlined.
Well, I had one little wry comment, and then if I could ask a question, I'd be really grateful.
Well, the comment is that it strikes me that the fact that men on death row have been forced to contribute their DNA to when the likelihood of their ever getting out and committing any more crimes is practically zero, I really think that their DNA is going to be used for some other purpose.
And I'm thinking about, for instance, what I've read about the cyborg research at MIT, for instance.
Well, that might be a little out there, but I mean, Professor, can you see a reason why people on death row would be required to give a sample of their DNA and what it might be used for?
The thing I would worry about is, and I can imagine scientists who would consider this as something to do, is to look at the DNA to see if they can detect mutations that might be some contributing factor to how these people ended up on death row.
Although given the selectivity in who ends up on death row and who doesn't among those who commit capital crimes, I'm not sure what they're going to find.
Well, I would like to ask the professor what his knowledge is and what his reaction is, what his thinking is about experiments that are being conducted on our own population testing non-lethal weapons like electromagnetic pulse radiation and lasers.
However, there have been a number of tests, Professor Ashley conducted on U.S. population centers with regard to, they say, benign little bugs, and the Defense Department just wants to figure out how quickly something might spread, you know, that sort of thing.
In terms of biological weapons research, there certainly are, I think, now well-known and well-accepted evidence that these experiments were done in various places, including are you from California, your show?
Nevada, you're near biological weapons research there anyway, both in Utah and California.
But there were experiments in San Francisco where, unbeknownst to the people there, there were bacteria released to see how much they'd spread, et cetera, with the potential dangers that people weren't aware of.
And these have come out, I believe, because records were finally released under the Freedom of Information Act to discover this.
So there certainly have been times, and it's not ancient history by any means, where at some level in our government and at some level of scientific experimentation, people went ahead and did things unbeknownst to the people that had potential dangers.
We also know about experimentation with LSD, with what the impact on people was, where people were given LSD and they didn't know they were being given LSD and sometimes serious consequences.
I think if you believed in evolution as firmly as most scientists do, you would not consider it junk DNA, that it's there for a purpose.
What that purpose is is really totally unclear at this point.
And in terms of understanding what it does, I think part of the approach, is to compare the genome of humans to the genome of other organisms and see what their proportion of junk DNA is.
I don't think they're doing it entirely for that purpose.
They're doing it for other reasons too.
But the mouse genome has come out, and more and more organisms are going to be sequenced.
Again, the pace of the development of machines that will sequence DNA and the pace of development of computer programs that can digest the information and give you back interpretations of information is constantly increasing, and it's making it easier and easier to do genomes.
I mean, when this first started only like 13 or 14 years ago, people wondered whether they could really get it done in 15 years, whether it wasn't going to be more like 50 years.
And they got it done much earlier than they thought.
That is, they got the human genome sequence done much earlier.
Now you can send a bacteria to like Craig Venter's old firm and get the bacteria probably DNA sequenced completely, the whole genome, in a week.
Wow.
So it's moving very rapidly.
And I think certainly for the evolutionists, it's going to be fascinating information.
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What percentage of this genome was unknown, I guess, for a different word?
There are things we don't understand, like genes that look like other genes.
For instance, hemoglobin is part of our blood.
And there are genes for hemoglobin.
And there are other genes for hemoglobin that don't seem to function at all.
But they've got the sequence maybe with one mutation in them.
What's going on there is not quite clear.
Did they just recently pick up the mutation?
And why haven't we lost it?
You know, the idea of evolution is you get rid of things, in fact, that are real junk, that they would not be of use to you, and they'd, in fact, be a disadvantage because they're carrying along this extra DNA.
If you've got a killer and he's been killed and buried, whatever, what happens if later on you then have a dead body somewhere, well, not sort of then, somebody's been killed in the past, there's been ongoing investigations, they're not all going to be cleared up.
They may need a DNA match to find out if this person, they're not going to be able to punish him once they've killed him, but they could eliminate other suspects if they've got his DNA.
I don't know if people everywhere are familiar with this case of the woman who was the jogger who was raped and severely beaten in New York.
And four other individuals were arrested, I think it was four or more, arrested and sentenced and convicted and sent to prison for that attack.
And recently someone else has confessed whose DNA was shown to be consistent with the rape of this woman.
And he's confessed and there's evidence that, in fact, he was responsible for it.
And that person was actually, in the meantime, convicted of killing someone else and conceivably could have been put to death, hasn't been put to death, but could have been.
So I think that's a wonderful, I don't know, wonderful, quite the nice word for it, but suggestion as to how that might be useful.
But that's only the beginning of the use of this technology.
I mean, it's almost blunder-bus, isn't it?
Even though it's fantastic that we're able to do that, it's blunder-bust off compared to what we're going to be able to do when we really decode how it all works, not just the genome itself, but the combinations.
Well, you know, there are, in some cases, there are supposedly safeguards.
I mean, people have really been very concerned about taking the DNA of everyone who's in the military or taking DNA of people, such as people in death row or other places.
And the military and the police argue that it's only going to be used for identification purposes.
Well, I've just published a book which is entitled Genes Making Waves, a Social Activist in Science.
And I hope the book does a lot of things.
I mean, in part, it's directed towards students of science, urging them to be socially responsible and to take more responsibility for the consequences of science.
But I think it also describes a lot of how science works and how it works in different laboratories, what the environment is within science, and also goes into some of the controversies I've been involved in that surround genetics, including the isolation of the gene back in the 1960s and some of the genetic screening programs that I was critical of.
And one of the major issues I've focused on, which is genes and human behavior and whether we really know enough about it and how the kind of information from that field has been used in what I would call destructive ways in the past.
People like me, I may not be representative of everyone, but I'm certainly representative of some fraction of scientists.
And I love science.
I love being able to solve problems and solve problems that have some relationship to life.
And basically, I think it's fundamental curiosity.
I've stayed pretty much all my life a basic scientist, even though basic science often gets translated into practical consequences.
But my true love is not necessarily the practical consequences.
That's kind of a bonus.
But rather understanding how a process works in self.
In the background, always is the knowledge that the more you know about how life works, the more use that may be to society.
And also, as we've talked about, the more problems it may create.
So it's a funny kind of mixed feeling I've had about science, but I feel that by involving myself in talking out in public about the consequences of genetic research as well as its benefits, that that's enough to satisfy me.
Professor, before you began to speak out, when you were involved purely in lab work, was there ever a moment that anybody within our government came to you suggesting that you could be of great assistance to our government?
It's not a kit that you can sequence your own DNA, though, is it?
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No, what it does is it takes work units from Stanford University, processes them, and adds them to what they believe to be the normal process for evolution.
Well, I had an Interesting discussion with people the other night where we'd come across an article that was suggesting that one of the consequences of having this information available in that way is that it will kind of reunite the scientific researcher from universities and institutes and companies with people at home actually discovering things also on their own.
And it seems to me that's a real possibility.
I don't know if that's the kind of thing you're thinking about.
I mean, I think that's a fascinating possibility and tying in the public much more closely with scientific research than anything that's happened in a very long time.
But also, I think it's conceivable, given the nature of the beast, that maybe I shouldn't have used the word beast, but given the nature of this area of science, that individuals at home using computers and analyzing data will come across things that scientists haven't, in their laboratories haven't come across.
I think it's, you know, I have, as I said, I have these very mixed feelings.
On the one hand, I think the information that's coming out is fascinating.
I point to things like understanding historical migrations of people throughout the world and our origins, and I think that's fascinating, as well as all the basic scientific information.
But the information is coming out very fast.
And, you know, there's one of my scientific colleagues over at Harvard who has publicly repeatedly stated that eventually all of us will be able to carry around a compact disk in our purses or in our wallets or whatever, which will have our complete genome sequence on it.
You know, how long will the beastly part of it be with us before, I mean, there's this big gap between the unraveling of the human genome and that brings with it, of course, tests, for example, for all of these diseases or many diseases.
More and more you hear about every day, it's in the news.
But this big gap between that and when we can begin to genetically treat these diseases, such a big gap.
And I think that it's not that we're not discussing it and the genome people aren't aware of this.
But one of the issues, first of all, is that these are one of the few kinds of products of the genome that really are potentially marketable by companies.
And a lot of companies are developing these genetic tests for the market and pushing them, which is, you know, they want to make money on this new technology.
But who's going to help the people understand what that knowledge means and how much will it be misrepresented?
People are confronted today with, for example, you take the case of Huntington's disease, which is a relatively predictable disease from a genetic test, that at some stage in your life you're going to come down with this and it's going to be a rather unpleasant degenerative disease.
So you could take a test when you're five years old, 10 years old, 15 years old, that will tell you that perhaps around the age of 40 or so you're going to start to develop this disease.
Yeah, there are some instances of, it's not so clear-cut, but there are at least one case of a marker where, on the chromosome, where you can say to somebody that you have an increased risk, it's not quite as anywhere near as strongly predictable as Huntington's disease.
But, you know, that kind of thing is coming.
And, you know, people who've been, even the woman who is a researcher, who's largely responsible for the project that led to the mapping to Huntington gene, announced when the test came out that she didn't want to be tested her own family at Huntington's.
Would you, if you had some history and had the opportunity to take that test, would you do so?
Because, I mean, there really is the strong probability that if it comes back positive, you're going to modify your life to the extent that you're not going to be productive anymore.
I mean, you're going to just go, I've had it, you know, and I'm going to, I don't know.
I mean, I've seen documentaries where they've interviewed a lot of people, some of whom wouldn't be tested and some would.
They said they wanted to plan for their children and all this kind of thing, the ones who did want to be tested.
So it depends upon the people.
I'll point out, it's interesting, one of the things that's becoming clear, and I've tried to talk a bit about the complexity of genetic disease, is the genes were found by looking at families where there was a strong indication that it was a heritable trait.
I'm talking about almost any disease.
And then the assumption was made, since in those families it was strongly heritable, that it would be true in every family.
And that turns out not to be the case.
I mean, even in Huntington's disease, a small fraction of the people live basically into their 90s without ever suffering from the disease.
But Huntington's is always considered one of the most determinant of diseases.
That is, if you have the gene, you've got it.
A small fraction there don't get it.
But the same thing has come up with screening for breast cancer.
They started out looking in families where there was a high prevalence of the disease and found that in certain families the women who developed the breast cancer had this particular mutation.
And it was assumed at the time that therefore everyone who carried the mutation had the same risk, very high risk of getting breast cancer.
But now they've gone out in the general population.
They found many women who carry this mutation who never get breast cancer.
My God, you know, a couple of years ago, maybe not even that long, I remember some women who, based on a genetic test, went out and had full, you know, mastectomy.
Well, I think what is now the standard, and that can change, is that if you are a member of a family where there's a strong history of breast cancer, then your risk is, and you carry that breast cancer mutation, then there's a very high probability that you would get breast cancer.
And then you have the choice of knowing that you will have some degree of protection by having a mastectomy.
You know, counseling and advising these days is supposed to be non-directive.
You supposedly give information and then allow the patients themselves to make the choice.
I'm not, again, this is not a subject I'm deeply knowledgeable in, but from my readings in that area, it seems to me there are lots of questions raised about the feasibility of it.
But, you know, there are companies, like there's a company called Geron, like Gerontology, one of whose major goals has been to develop anti-aging genetic therapies of various sorts.
Do you know whether we have discovered, or at least to some degree, the little switch or the fuse?
I know there's the telomeres, and I don't know a whole lot more about it, but I know somewhere in the genetic code, there's probably something that says we will get older, cells will begin to die faster than they regenerate.
You're really getting outside my expertise in terms of switching bodies.
The cloning thing, I would argue that the expectation that cloning yourself is going to be yourself certainly and have the same thoughts as you, et cetera, is a very, very questionable prospect.
We have just basically no reason to think that an individual who's cloned from another individual's DNA is going to have anywhere near the same life course that the original individual had.
Overall, I would say if you're talking about the complete characteristics, I would be shocked.
I can imagine there are certain things that could be similar or very much the same.
But I still think that we are all a product of our genes and our environment.
And people who grow up at different times in the history of the world, grow up in the 30s or the 50s or the 70s or the 90s, I think are going to have very different experiences that influence, I mean, for instance, I don't know what I think of this, but I grew up studying and doing all my work, never listening to music, which everyone listens to today, doing everything.
I don't understand how people even function listening to music.
And I'm sure that has a very different influence on people than not having music.
But I mean, there's just so many different aspects of our family life and our societal life that have changed that I'm sure there'll be changes.
I mean, people, for instance, there may be a genetic basis for perfect pitch in Music.