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Sept. 20, 2023 - Dr. Oz Podcast
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Cure for Alzheimer's: Could This Nasal Spray Improve Symptoms? | Dr. Oz | S11 | Ep 35 | Full Episode
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- The secrets to aging backwards.
And what you can do now to turn back the clock.
We're cracking the code for aging.
Plus, the dish crew is serving up...
It's almost like a party in my mouth.
The ooeyest, gooeyest, cheesiest, mouth-watering meals.
Everybody grab a corner.
We're gonna pull apart.
Coming up next.
Are you ready for season 11?
Yeah!
All year long, we're gonna be bringing you news to the front lines of the war on Alzheimer's disease.
And today, breaking news on a nasal spray.
Researchers say it could improve symptoms in the brain.
But first, on a personal note, a few weeks ago I made a tough decision to share my own family's connection to the disease.
And I still cannot believe the response.
In my family we have three generations of females that have passed away with full-blown Alzheimer's disease.
My mother had Alzheimer's and it was so slow coming on that we didn't realize it for quite some time.
I sometimes will meet people that I have been told I've met many times before.
I cannot remember their name or where I met them before.
I forget passwords, family phone numbers, and ingredients in a recipe.
I'd love to know what I could do to maybe lessen the risk.
I believe that There is hope for people who think they might be getting Alzheimer's.
A cure would be great, but will it come in time to improve the quality of my life?
In our family, and I'm sure many families like us, we're pretty desperate.
Well, thank you everyone for sharing your Alzheimer's stories.
There's a new treatment that's got Alzheimer's and all the folks worried about it buzzing.
Can a nasal spray actually protect your brain from Alzheimer's?
Joining us now is brain health researcher Max Lugavere and director of the Alzheimer's Prevention Clinic at Weill Cornell Medical Center, Dr. Richard Isaacson.
Tell us more about this new nasal spray and what it could mean, what the research is showing.
So, most people don't realize, but the metabolism in the body, when someone eats sugar, something gets secreted, it's called insulin.
You may have heard about insulin, it's a hormone.
And you secrete insulin, the body does that, and it breaks down the sugar.
But there's a side effect to that, and that's inflammation.
And inflammation in the body is like pressing fast forward button on amyloid, the bad stuff in the brain.
So if we can inhale, A very specific type of insulin to fight that amyloid and to reduce that inflammation, we can protect against Alzheimer's disease.
Do folks with diabetes have more Alzheimer's?
Believe it or not, Oz, people with diabetes have more than twice the risk of Alzheimer's disease.
So it's super important.
Get your blood pressure checked, get your blood sugar checked, get your cholesterol checked, and if you have any of these risk factors, fight them to reduce your risk.
So, Max, what does it mean?
This idea zeroes in on a concept you've been sharing with me for quite a while now, which is there's a diabetes-Alzheimer's connection.
Yeah, I mean, a growing number of researchers and clinicians alike are now beginning to refer to Alzheimer's disease as type 3 diabetes, a form of diabetes of the brain.
And as Dr. Isaacson mentioned, when you have type 2 diabetes, which, I mean, you've shared statistics many times on this show, I mean, your risk for developing Alzheimer's disease increases anywhere between two and four-fold.
So the diseases are intricately connected, and though we're still trying to unravel exactly, you know, how they're connected, This insulin link is very interesting and it offers, I think, a clue as to what might be a potential cause for Alzheimer's disease.
So Max, let me show everyone the theory behind this insulin nasal spray.
So in a healthy brain, as Max was pointing out, right?
Insulin is important in preventing those harmful plaques.
I'll put them up in here.
They look like that.
Those harmful plaques that are associated with Alzheimer's, right?
But when your brain does not respond properly to insulin, like in diabetes, this is what happens, that plaque begins to accumulate and builds up into dangerous amounts, blocking these different neurons, these different nerves.
So with the new nasal spray, the idea is you put the spray up your nose, you squeeze it, and scientists think that once the insulin gets shot up into the brain, that insulin will help the brain fight off the bad plaque.
So these plaques will melt away, ultimately helping you defend against Alzheimer's because now the neurons can talk to each other again.
All that sap gets pulled away.
Now, Dr. Eisenstein, this is not the same insulin that we're talking about when we give people injections for their diabetes.
No, we don't want anyone at home going and trying to, you know, put their insulin up their nose.
That's not it at all.
It hurts with a needle.
Oh, forget about it.
Let's skip that.
But someone can grab the bull by the horns and they can eat less bad sugars and processed foods.
They can take their insulin or diabetes medicines as directed by their doctor.
But in the future, one day, I hope, that we're going to have an easy way to get the insulin in the brain to fight the plaques and fight Alzheimer's disease.
And you're optimistic there's new research going on, continuing right now, to prevent Alzheimer's.
Give us one action step.
You're on the cutting edge.
What should we all do to starting today?
Number one, get out of your comfort zone.
Learn something new, a new language, a musical instrument.
You know, maybe, Max, I can drag you to a sports game.
Max loves sports.
He loves baseball.
Give him a haircut first.
You're gonna come to a Yankees game with me.
We're gonna take the stairs, we're gonna go all the way up to the 400s, we're gonna get exercise, and we're gonna socialize.
Because socialization, exercise, and learning something new is great for the brain.
Alright, so I want you all to follow Dr. Isaacson's advice.
I want you to stop, snap, and share this action tip.
I'm going to do it too.
Get your phones out.
Take a picture of it.
Ready?
Get out of your comfort zone.
Now, do something new.
It's good for your brain.
And you'll remember having done it.
Send the reminder.
I want you to take the picture to your friends.
I'll send mine to my kids as soon as we get off the air.
I'll be right back. - A Betrayed Wife.
She was controlling.
Secretly records her husband.
When did you first discover that she had a listening device like this?
She took my husband away.
I felt it inside of my jacket.
Then kills his girlfriend.
She described in great detail what she was going to do.
Before killing herself.
I'll always remember that day.
I was just never gonna leave.
All new Oz.
That's coming up tomorrow.
Poor sleep and anxiety sadly have become hallmarks of everyday life.
But are they also early indicators of Alzheimer's disease?
Well, we're about to find out.
I asked Dr. Aisha Sharzai, author of The Alzheimer's Solution and co-director at Loma Linda University Health, one of the blue zones, by the way, where people live the longest, is here to help us figure this out.
First of all, sleep and Alzheimer's, is there really a connection?
There definitely is.
Sleep is such an important state and a stage of our day.
I think it's the most important time of the day.
This is the time when the brain actually restores itself.
And there's a lot of research that shows that when people don't go into the deep stages of sleep, they increase their risk for Alzheimer's disease.
And the bat protein, amyloid beta protein, actually rises up when we don't get a good night's sleep.
Even one night of bat sleep raises the level of amyloid.
And unfortunately, you can't really make up for it during the weekend.
How many of you have had a bad night of sleep until last week?
Yeah, I thought so.
We've all had that.
Okay, come on over here.
Let's talk about what's really going on inside your brain.
It's not all bad news, but while you're sleeping, your brain is supposed to be doing some important things.
So think of your brain as a giant building, right?
That giant office building at night has a cleaning crew that comes through there, and they're picking up all the trash and doing all kinds of other things, right?
But what's most important is they take all of your short-term memory, things that happen today, and they store it as long-term memory.
So what happens today gets filed away appropriately.
Like, for example, when Becky, right, said that thing at work, you know how that always happens, right?
It gets filed away, you never forget it, right?
Because you're never gonna wanna forget what Becky said so you can get her back.
Anyway, the janitors are actually cleaning the toxins out of your brain every night.
And while you get proper sleep, that's what's important, when you wake up, you're gonna feel refreshed, because all the trash has been dumped, carted away with the trucks, right?
And you can go at full capacity again because you're all cleaned up.
But when you don't get the right sleep, or at least enough of the right sleep, those janitors, they're actually called microglia, they go wild!
They're banging their heads into the walls, they're making a ruckus there, they don't know what their job is, they start to behave very destructively.
This is, I think, a pretty good reflection of what happens when you haven't slept well.
And again, even one night's a problem, but of course it's a much bigger problem if it happens night after night after night.
Absolutely.
So, if not getting the right sleep is harmful for the brain, if you take a sleeping pill, for example, does it make a difference?
Short-term, I think sleeping pills are okay.
I mean, a lot of people have sleeping problems, but it should never be used as a long-term solution because sleeping pills can actually damage the deeper stages of sleep.
And they've done studies on it.
People actually taking long-term sleep medication have a higher risk for developing Alzheimer's disease.
And how early does a sleep problem start in your life?
Does it vary?
So it can actually start decades before the manifestation of the disease.
So it can be a contributor.
It can also be a sign of Alzheimer's disease as well.
And they go hand in hand.
Bad sleep, more pathology of Alzheimer's disease.
More pathology of Alzheimer's disease, bad sleep.
So there's a very close relationship between the two.
So the good news is that there's evidence showing if we improve our sleep, it could help prevent the disease that we all fear most, Alzheimer's.
So we've got a quick I show quiz for you.
You can take right now to determine your sleep efficiency.
They're all yes or no questions.
Just keep track of how many yeses you have, right?
Do you not feel refreshed after sleeping eight hours in a night?
Again, yes or no, pretty straightforward.
Do you have a confused body clock?
Sometimes sleep during the daylight hours and you're wide awake at night.
Everything's flip-flop, right?
Yes or no.
Do you find yourself frequently snoring?
You might want to ask the person next to you if that question is yes or no.
How many of you wake up many times in the night?
And again, the question here, yes or no?
And are you getting less than seven hours of sleep a night?
Yes or no?
And finally, have you worked the graveyard shift for more than a year?
Yes or no?
If you answered yes to three or more of these questions, you may want to start improving your brain health.
How about the anxiety connection to Alzheimer's?
How big a deal is that?
Oh, there is a huge connection between anxiety and disruption of the normal mechanisms of brain function.
So when we're anxious or when we are stressed, the bad type of stress, not the good stress where we actually put ourselves and it's ours, the bad stress causes disruption of parasympathetic and sympathetic nervous system and the autonomic nervous system.
And so bad hormones and chemicals are created and these chemicals actually go around And damage the connections between brain cells.
So it increases memory problems, it increases chances of having bad focus, bad attention, you can't really retain information, and you're not allowed to be the best version of yourself on a regular basis.
So as an expert, give us a tip before we go about how you might reduce anxiety, get to sleep you need, and maybe avoid the Alzheimer's we all fear.
Gosh, I could talk to you about this for days.
And, you know, as we've mentioned in our book, one of the quickest tips and one of the best things that we can all do is never, ever take your worries to bed.
Separate your bed from your anxieties and your daily activities.
Park it outside.
Either write it down on a notebook or a whiteboard or, you know, a piece of paper.
Leave it on the table and address it tomorrow.
All right, here's something that I think I can actually use.
Good evening, Dr. Oz.
How can I help you?
Assistant, please remind me to pick up Lisa's dry cleaning, which I never do, read scripture for next week's shows, and call the hospital for a flu shot.
Yes, Dr. Oz, I'll remind you tomorrow.
Have a good night.
Perfect.
Perfect.
My mind is clean.
I can restlessly go down there.
Thank you as always.
Of course.
Wonderful advice.
My pleasure.
Dr. Shazza and her husband, I want you to check out their new song on HealthyMindsInitiative.org.
It's about Alzheimer's you'll enjoy.
Yes.
As you go to break, a clever new way comics are improving their lives, rather the lives of Alzheimer's patients.
Take a look.
Following her mother's Alzheimer's diagnosis, Dani Klein-Modoset hired a comedian to interact with her, and the positive impact was undeniable.
So Dani founded Lafter On Call, and she and a team of comedians are bringing the experience to seniors across the country.
This really works, and it's super powerful.
The connection is so rewarding and beautiful to witness.
Here's five ways you can show up for someone with Alzheimer's in your life.
Breathe.
Be honest.
Be present.
Say yes to wherever their mind goes.
And don't be afraid to be silly.
Coming up, the new rules to reverse your aging from the outside in.
Simple things you can do right now to turn back the clock.
Everybody dreams of reversing the aging process, the ability to feel and look younger with each year, even though you're growing older.
While we all tend to believe that getting older means declining, self-proclaimed biohacker Dave Asprey's got a very different idea.
The guy that got America putting butter in their coffee is here to give us three ways, he says, could help reverse the aging process.
Please welcome the ultimate biohacker, my good friend Dave Asprey.
You know, you're very proud that you're a guinea pig.
You try everything.
If I had never heard of anything, I'd call you and say, have you tried it yet?
Have you ever regretted, maybe because the signs change, you're in the middle of it, you wish you hadn't started?
In my 20s, I was really heavy and my gut was bad, really bad.
So nothing worked that was supposed to work, and I bought this electrical pill from Russia.
It didn't even have writing in English on it.
And you swallow it, and it's supposed to shock your intestines.
God.
And it got stuck right here, so for two hours I was kicking like this.
Oh no!
And I was kind of scared, so I hopped around like this until it moved.
Don't do that.
I'm sorry, how did it actually, if I can ask, electrical shocks coming out of this, how did it actually come out from the bottom, number two?
The way you'd expect.
It was a little pill, but...
It wasn't shocking you on the way out?
I did, the whole time.
It was just not a good idea.
Let's go back to when you were in your 20s.
I've got a picture that I've seen before that everyone should see of you.
It's very different, Dave Asperger.
What were you thinking?
What were you feeling?
I know you said you actually at that young age felt old.
When I was 14, I went to the doctor because my knees hurt when I played soccer.
And I came out with a diagnosis of arthritis.
That's for old people and I'm a teenager.
What's going on?
By the time I was 26, I had less testosterone and more estrogen than my mom.
And I started to have brain fog to the point that I bought disability insurance.
I can't remember what's going on here.
And the lab test said high risk of stroke and heart attack.
I'm starting to think I'm old and I'm not even 30. And it was scary.
I felt like I was losing control.
That's what my life was like.
That's what made me so passionate about living a long time and not getting old as I age.
So to that point, Dave's got a new book called Superhuman.
It's articulating his belief that we can all live to age 180 by hacking our body.
And you're going to go first, right?
So I hope you all have 401ks out there because you need bigger retirement packages.
Right?
It's a big promise.
Why 180 and what's the big change?
I mean our no life expectancy now is maybe 120 and that's very few of us getting to be close.
So we know we can do 120. What I'm counting on is that in the next hundred years we're going to be able to do 50% better.
And now we understand what's making us old for the first time ever.
So now we can hack it.
Depending on the future.
All right, Dave believes that the mitochondria in our DNA is one of the pillars of aging that we can control.
Remember, the DNA is critical, but the mitochondria is the energy package.
Come on back here.
So here's a way of thinking about it.
Let's go inside your body.
Let's go inside your cells, right?
And Dave says, imagine your body, your cells, as a house, right?
And the mitochondrial DNA is the wiring, right?
It's the lighting up there, right?
They start to blink on.
The air conditioning, thank goodness you got some dehumidifiers.
You even got a fire going, right?
Gas controlled but electrically powered, right?
Once the mitochondrial DNA is damaged, this beautiful house changes.
All of a sudden, it's still standing, but who wants to live in a house with everything busted, right?
The microwave blew out, the screens don't work, the air conditioner is busted, the bulbs have blown out.
Nothing's the way you want it.
This is the houses that many of us live in.
It's still there.
From the outside, it looks okay, but on the inside, it's not right.
And Dave says damaged mitochondrial DNA can lead to every one of the four big killers that we all fear the most.
Diabetes and Alzheimer's, which I've been talking about a lot this season.
Even cancer.
And heart disease and diabetes obviously travel together.
So Dave says adding energy fat is the first trick to reversing aging.
Now this concept of energy fat is intriguing to me because most of us grew up thinking fat wasn't so good.
We started to challenge that.
But the idea that fat could actually be your main energy, not carbohydrates, is shocking to a lot.
It's really shocking because we've all heard fat makes us fat.
There is a kind of fat that doesn't get stored in the body.
Instead, it gets burned directly as energy.
All right, so he's gonna show us his new take on the famous bulletproof coffee using energy fat.
So first off, please remind everybody what bulletproof coffee is.
And this is the main reason America got to fall in love with you because you introduced a concept that people Played with, dabbled with, coffee is something that's good for you, but you actually hacked it with the butter.
Actually, you explain it.
Sure.
It turns out when you put milk in coffee, milk disables the plant compounds in coffee that are good for you.
So instead, just put the same fat that's in the milk, grass-fed butter, and it tastes amazing, and you add C8 MCT oil.
This is the extra fat you're adding now to sort of turbo charge it.
This is the energy fat.
You put it in there.
It tastes just like coffee, like a latte, but something happens.
I've lost a hundred pounds.
I've changed my brain.
I'm young again, even though I'm in 140s.
A hundred pounds.
Again, this is a key point.
If you want to hack these things, experiment.
You didn't just do everything.
You did them one by one.
You were very methodical about it.
But I think trying bulletproof coffee, again, which you've talked about on the show here, butter with coffee, is a wise hack.
I do think the caffeine lasts a little longer.
It does.
So you get a little more boost, you don't have to take quite as much caffeine into your body.
And I had not thought of adding these kinds of fats.
C8 is the, C stands for carbon, so it's a very specific one of those.
It'll theoretically bump up your ketones, right?
So if you're trying to stay ketotic, it might help you there.
In fact, four times more than coconut oil.
So this is, in university studies, the one that's shown to raise ketones the most.
All right, so I'll toast to you on that.
If you're on one of these ketone diets, Give it a shot, Dave Asprey.
Coming up, two more of Dave's tricks.
He says he can help reverse the aging process.
Plus, we're going inside, listen carefully, Dave Asprey's poop, where no man should want to go.
But we're going there.
Stay with us.
An Oz Skin Care Investigation.
We go undercover.
This one says it works in a week.
And what we found will shock you.
You don't know what you're putting on your face.
All new Oz.
That's coming up on Friday.
We are back with the guy who plans to live until he's 180.
Dave Asprey, who says getting older no longer means your body has to decline.
And his next trick to reverse aging deals with keeping your brain young, which we all want to.
The number one thing people complain about, and you argue it's about prebiotics, not probiotics, prebiotics.
Why?
All sorts of new studies are showing that it's how you feed the bacteria in your gut that determines which ones you'll have, and whether you have old people bacteria or young people bacteria.
And we outsource digestion to our bacteria.
So Dave says, the gut-brain-body connection is undeniable, and we are years away from knowing all the subtleties, but as a glimpse into the future, he turned his own poop into a science experiment.
So come on down.
We'll be passing samples out later to the audience.
Let's look at what was found in Dave's poop.
Now, good score means there's more richness, right?
Which in turn can provide more resilience to your microbiome bio-ecosystem.
And again, you outsource digestion, so if the bacteria aren't right, you got a problem.
Okay, before going on prebiotics, your microbiome richness score in your poop was a 61. After taking prebiotics for a few months, Dave's active microbial richness was 158. Don't applaud, because you don't know what that means yet.
I don't either.
How big a deal was that and what does it mean in terms of her overall ability to age to think and do everything in life?
It's a huge deal, Dr. Oz.
I am a nutritional expert and I didn't have enough bacteria because I travel so much that I wasn't eating enough vegetables.
So these prebiotics, things like asparagus, Brussels sprouts, sweet potatoes, I just couldn't get enough from restaurants.
So I added these prebiotic fibers, and this is the bacteria counts, the number of species of a young person.
So I went from having an old person's gut to a young person's gut in three months by feeding the good guys.
So this is sort of, to me anyway, like having a knee replacement if your knee's busted or hip replacement.
I mean, as we get older, we're gonna have things fail on us.
And I think one of the things, even at a younger age, that can fail is the bacteria that are supposed to cooperate with us.
So, antibiotics might change this, or a bad diet for a while might change it.
So, if that's a pretty easy thing to hack, we oughta be doing it.
Next thing Dave says that can help reverse the aging process is what he likes to call metal bashing.
Is this a musical term?
It is indeed, not really.
It turns out, if you think about it, if you have stuff that stays stuck in your body, if you're gonna live to 180, like I'm planning to, that means that you're gonna get an awful lot of crud built up, and one of the cruds it builds up is toxic heavy metals.
They're present in our environment, things like lead, mercury, nickel, and if you don't get rid of them or stop them from coming in, by the time you're old, you're going to be disabled by these things.
What specifically would it do if you're mercury level?
My mercury is really high.
I got a letter from the State Department of Health.
And I think I take good care of myself.
I'm just eating the wrong kinds of things.
So what does it do?
It affects your ability to make energy in your cells themselves.
It increases your risk of cancer, especially breast cancer, and it lowers cognitive function, and it increases your risk of almost every disease.
It adds up quite quickly.
So show us an important food group.
It's fish.
They can put us at risk for metal toxins.
And a lot of you know about the warnings around tuna, but there's a lot of issues out here.
Please explain them.
So a lot of people might not know swordfish and tuna are the highest ones, but if you were to instead...
Macro, which I happen to adore, unfortunately, is also a problem.
But if you move over here, you see salmon.
Salmon can be at the low to mid-range, especially if you get sockeye.
And sardines, though, because think about it, they're this young baby fish.
The fish over here may have spent 50 years eating other fish, building up all that mercury.
I don't want 50 years worth of mercury buildup in my brain.
That's why I'm gonna go for the sardines.
So I become a huge sardine fan.
Anchovies, I eat all these.
Salmon, obviously, is my main staple.
But you have a little hack.
Here's a little hack.
Shall we squeeze these?
Yes, what does lemon do?
What lemon does, it provides vitamin C. And vitamin C can help you not absorb the mercury that's in the fish itself.
And if you add those vegetables, those fibrous vegetables that I talked about before, any sort of fiber is going to help to bind to the mercury so that you don't get it in your body.
Plus, it tastes good.
So you're winning on every front.
I love when these traditional ways of preparing foods turn out to have additional advantages you never knew about.
That's why if you have steak, you should have tomatoes with it, because it's sort of an antidote to some of the issues.
This is one I hadn't thought about, but thanks for educating me.
Congratulations on all your success, Dave.
Don't forget to check out Dave's fantastic new book.
It's called Superhuman, and the best part is that everybody in our audience is going home with a copy of Dave's new book, Superhuman!
Who writes this book?
We'll be right back.
Coming up on the Dishanaz, new takes on the ooey-gooey sandwiches you all love.
I mean, from meatball sliders with mozzarella to the ultimate grilled cheese with a secret ingredient you'll never guess.
No one's going to be hungry today.
If there's one thing that brings us all together, it's food.
So we're calling everyone to the table to dish on everything, from the latest food hacks and trends to everyday recipes you can make for dinner tonight.
It's simple, it's celebratory, and most of all, it's about having a great time in the kitchen.
What is going on?
I'm trying to help.
Let's ditch.
Oh my goodness.
We're back with The Dish on Oz!
And today, look what they're doing!
They're bringing you a new twist on the hot cheesy sandwiches you love!
Oh, can I help Elise?
This is unbelievable.
Bethany, what are you dishing?
What is this thing?
We are giving you guys the best way to take a regular grilled cheese and make it magic.
Oh, this is much better.
Okay.
And making a pull apart.
Wait, this is the best part, you guys.
We're making a pull apart meatball oven baked slider that is going to be the top of your next Football Sunday Funday.
This is ridiculous.
What are we holding?
It's heavy.
You know what?
You keep going.
You know the best way to do it?
You know what you do when you have a big sub like this?
What?
You give it away to your friends.
I'm giving this to the audience.
By yourself?
By myself.
You guys, keep going, keep going.
I'll be back to taste.
Look at this.
Look at him go.
Make it away.
Oh, good man.
We gotta share.
We gotta share that delicious looking sub.
I've got a little bit of the New York area finest on my hair.
I was thinking about this show, and sandwiches feel like everyone's school lunch, and we've had them a million different ways.
And they can feel a little ho-hum, but then I started thinking, some of my favorite memories, and food memories specifically, are about sandwiches.
They're so local for me.
So down at the Jersey Shore, I spent a lot of my summers as a kid.
There's a restaurant down there that has the most Beautiful hoagie, and it's the simple things that make it delicious.
It's like the perfect bread, and the perfect amount of cheese, and that little dash of vinegar, and that sprinkle of oregano.
And I think that's what makes sandwiches so amazing for us, is everyone's got that one that's just like, this is my all time favorite.
Gina, tell us, what's your favorite one?
What's your favorite sandwich of all time?
My favorite one would be in Atlanta, this place called Agassi.
It's a burger.
But it's not really a burger.
Okay.
And it's juicy, and it has all these flavors into lettuce and tomato, Dijon mustard, and they put on some kind of little sprinkle rub.
Look at your eyes.
You're like, you're going there.
I know, I'm going there.
I'm sorry.
You're traveling.
I'm greedy, okay.
But it's almost like a party in my mouth.
Oh, yeah.
Like, it's just, and I want to chew it slow, like...
Okay, we're gonna let you have that.
Vanessa, what about you?
What's your favorite?
Well, you're right about like seasons and stuff, like summertime lobster rolls, the best bread.
Yes, buttered roll, has to be a buttered roll.
Clam boats from Howard Johnson's back in the day.
Anybody remember Howard Johnson's?
We're talking, yeah.
Even our friendlies back in the day, clam boats, yeah, yeah.
But don't you, this is what I love, there's an art form to the perfect sandwich, and everyone has, you think it's a simple thing, you think it's two slices of bread with a bunch of stuff in the middle, it's not.
It's our personalities on toast.
So Jameka, I know.
I love that.
Since you're our science major over here, tell us about the scientific formula behind a perfect Sammy sensational sandwich.
Oh, yes.
I have studied long and I have studied hard to get this perfect sandwich for you all, okay?
Because it is all about the bread.
I mean, come on.
It's raining bread out here, y'all.
Hallelujah!
Good foundation.
My dreams have come true.
It's all about the bread.
And if you have, like, a wet filling, like a chicken salad or an egg salad, you want to toast the bun.
So that way you gotta have a little space there so that the bread won't get soggy.
Of course.
Because you don't want that soggy bread.
Who wants a sandwich with soggy bread?
Nope.
No, nobody wants that.
And then, okay, so you gotta go with the fillings and the ratios, because we've all seen a sandwich that looks like this.
I mean, come on.
It's great to take a selfie with, but who can eat that?
Nobody.
So yes, you can't get your mouth around that.
You can't get the flavors.
We don't want that sandwich.
So we bring it down just Just a little bit, so that's something you can wrap your hands around, really get into, so you have that balance in life, right?
Yes.
Come on, yes.
Right.
So you heard it here first from the sandwich expert.
Oh, yes.
Okay, well, first up, I did promise you guys some baked sliders, so let's dish those details on the perfectly proportioned ala jamika pull-apart meatball oven baked slider.
Vanessa and Gina, you guys are gonna show us how to make these meatballs and the sauce.
We've got equal amounts of pork and beef, and these are garlic and onion sauteed together in olive oil.
Yum, yum, yum.
That's a good start.
And then we have breadcrumbs and milk, equal proportions, that are soaked together so it's nice and soft.
I love that.
One of the best tricks for a juicy, tender meatball.
You gotta have that.
With the milk and the breadcrumbs, okay.
And we're gonna add in one egg.
There we go.
And some Parmesan cheese.
Yum, yum, yum.
Lactic love.
Lactic love.
Here we go.
And some parsley.
Oh, yes.
Give it a little color.
Yes.
Scoop with ice cream scooper.
Scoop it, yep.
We're gonna scoop this out with ice cream scooper, and we're gonna just drop it right in our sauce.
Lovely.
So they're gonna simmer in that sauce, cook, and soak up through that wonderful tomato flavor.
You guys keep working on that.
We, of course, have our beautiful, ready-to-go, fully cooked meatballs simmering in that gorgeous sauce.
That looks good.
Jameka has toasted bread here with mozzarella cheese layered on top.
So it has a nice little barrier.
Shingled.
Yes, so we have the shingled cheese on there, a nice little barrier, so it won't completely soak into the bread, but the cheese all beautifully melts with that hot meatball and sauce.
You know, I think this is one of the best tricks, actually, is to have that cheese as a barrier for the bread, because you're absolutely right.
It does make it so that you get that little bit of saucy action without losing the crunch and texture of your bread.
I'm gonna keep cheesing here.
A little parmesan.
Oh, yes.
And then you put another slice of cheesy love on top.
And then...
Oh yes, and then I have the top of the bun here, and it's just been toasted and brushed with a little garlic, garlic butter.
Oh gosh, this is so, I can't even talk.
So it's like a garlic knot plus a meatball bun.
Yes!
Nice and garlicky and toasty on top.
Don't say we never did anything for you.
Oh my goodness, okay.
I'm going into the oven.
This is just gonna need to toast, so about 20 minutes, 50, 20 minutes.
Just so the cheese melts and everything comes together, that's it.
Check this out.
Here she is.
Stay there.
Hang on, let me get my hot mitts on here.
Bring it out, bring it out.
Get you a nice hot one here.
Bring it out, bring it out, bring it out, bring it out.
This is happening in your house.
I can smell this.
Let me put it right here.
Let's bring it over here so we can pull apart.
Come on now, come on now.
Everyone will follow wherever that sandwich goes.
The smell coming off of this little bad boy.
Cheers to the beer.
Okay, come, come.
Everybody grab a corner.
We're gonna pull apart.
Ready, everybody grab a corner.
Four corners for five friends.
Here we go.
Let's go, let's go.
One, two, three, pull!
Yes!
Everybody got a meatball!
Oh, look at that cheesy pull!
Yum, yum, yum.
Come on.
And everybody's got a meatball of love.
Oh!
Yes!
Vanessa, it's just heaven.
It is heaven.
It is delicious.
Gina's actually drooling, which I really love.
Wipe your mouth, baby.
Catch it right there.
Catch it.
In a good way.
Coming up, we're making magic out of regular grilled cheese, but this is the die for.
Oh, yeah.
- Come on! - Stay with us. - Come on! - An Oz Skin Care Investigation.
We go undercover.
This one says it works in a week.
And what we found will shock you.
You don't know what you're putting on your face.
All new Oz.
That's coming up on Friday.
We're back with the 10 Shot Eyes, the Big Sandwich Show today.
I'm grading cheese because Vanessa Williams and Daphne are taking regular grilled cheese, and they're making it magic.
So, dish Rory, what's going on over there?
Mm-hmm, grilled cheese, you guys.
Vanessa and I are gonna dish the details on one of my all-time favorite grilled cheeses.
It's grilled cheese with roasted cauliflower and caramelized onion and a spicy mayo.
And it's kind of the bomb diggity.
Okay.
Very curious, huh?
I really love a grilled cheese and I was looking for a way to make one that was a little bit, this ain't your kid's grilled cheese.
This is an adult grilled cheese.
It's delicious.
Okay, so Vanessa is caramelizing some onions over here.
Yes, I am.
And part of, I think, creating this glorious sandwich is building that flavor layer by layer so you can see how deeply golden brown we made these onions.
And that is just all about cooking them low and slow.
That looks gorgeous.
And one little sneaky tip, make a whole bunch of those and you can freeze them in little ice cube trays and then you have them and just store them in a plastic bag.
Then you have them to pop into sauces, use an omelette, whatever you have there.
Okay, so the next trick is to roast up some cauliflower florets.
So, you know what, you want to be careful.
This is the one sort of tricky piece.
I make a flat side by cutting off some of that stem and then I'm just going to work like my way here, making sort of half inch thick slices.
You wanna make sure that core stays intact so you get nice, nice little thin layers like this.
Lay those out on your baking sheet.
Perfect for a sandwich.
Look at that.
It looks like a pretty little brain.
Come on, oil.
Ooh, yeah, girl.
There we go.
There we go.
Okay, a little sprinkle of olive oil here.
I like to cook with olive oil when I'm roasting my veggies like this.
A nice little healthy fat and they give it such great color.
A little sprinkle of salt.
And that, hey, Vanessa, will you throw that in the oven for me, please?
I will put it in, yes, the oven.
Thank you.
So just keep an eye on that.
You want a nice golden brown.
Let that cauliflower roast all the way through.
And then, ladies, you've got my spicy mayo over here.
So I'm just gonna use regular mayo.
You can make it yourself if you feel like it.
Jalapeno is what Jamika has.
And then some grated garlic.
Fine dice on that jalapeno.
Oh, yes.
I was up all night.
Oh, beautiful.
Look at that.
Thank you so much.
Okay.
And some garlic.
Get that for me.
Yep, so give that a quick mix together.
And this is, again, part of that simple sandwich, but making it elevated, is a little bit of flavor like this.
This kind of condiment goes a long way.
Beautiful, thank you so much.
There you go.
Okay, so I added that mayo.
Now a little bit of that caramelized onion, if you would, please.
Absolutely.
Yeah, don't be stingy, we love that.
Be stingy.
Sweet, delicious, little boost of flavor.
Oh, yes.
There we go.
Oh, yes.
Perfectly cooked.
Beautiful.
I'm going with, now here's one of my tricks.
I go cheese first, then I go with a layer of that, already you guys, already, already.
And then I go cheese again, because you want it to be sticky.
Cheese is your glue, you want it to hold the bread together.
And as that cheese melts, it's going to hold onto a little bit of fresh peppery arugula.
Love arugula.
Now, because I don't believe in undressed greens, a little bit of olive oil right on that arugula, and a little bit of salt right on top of here, Yum.
Throw some for Elijah.
Okay, now put that top right on here.
And now here's one last trick for your gorgeous grilled cheese.
Vanessa has it going here.
Put a little butter in your pan.
Let that melt before you add your bread.
Here we go.
Give it a lick.
Oh, look at that one.
Make enough for your friends, you guys.
There we go.
And if you make a whole big batch, you can keep them warm in a 300 degree oven until you're ready to eat with all your buddies.
Ooh, wow.
Now, here's the thing.
You wanna make sure, see this gorgeous golden brown color?
That's gonna take four to six minutes, and until that cheese is nice and melted, that's when you know it's done.
We are gonna take a taste of this Not yet.
I'm going to make you wait for just one second.
Now, I shared with you my all-time favorite grilled cheese.
I want to hear, what's your favorite grilled cheese, Vanessa?
I would say, growing up, the American cheese.
Classic.
And I used to put a little bit of bacon and sliced tomatoes in it.
So the bite would, like, squish in my mouth, but also have the bacon salt.
It was delicious.
Oh, delicious.
Love it.
That sounds so good.
Crispy bread.
Mm, mm, mm.
Nice.
Well, our test kitchen, because we put this to the test, you guys, ranked the best cheeses for grilled cheese sandwiches.
Are you guys ready to hear these results?
Yes.
Absolutely.
Yes.
Well, number one was American.
Yes.
I think so.
Sometimes you just want that perfect classic.
That's it.
It's so good.
American white bread.
Number two, you guys, medium cheddar.
I think this makes sense.
I'm curious what the chef's think too, because it's like, it's that little bit of pepperiness without overwhelming the whole sandwich.
It still melts really beautifully.
Is that anyone else's favorite around here?
I love mild cheddar.
I think that's my favorite.
It's a good flavor.
Yes, and it gives it a nice pull away too.
A really nice pull.
Because you gotta have a cheese beard going on if you have this.
Oh, yes, you gotta have the strings.
That's the side of the section.
Pull away.
Number three, we've got this.
Green hair.
Ooh, fancy!
It does have that gorgeous melt.
It is.
It's a good melt.
And number four, some people out there like it's smoky, which means they like their Gouda.
Yes.
Gouda.
Gouda's fun to play with, like those barbecue flavors if you want to.
I heard Gouda, I heard cheddar, I had all the things I needed to hear.
I grated them, they're all ready to go.
By the way, it does look like a brain.
I'm very proud you noticed that.
See, I listened.
If you don't get to taste it yet, when we come back, we're going to do that.
But we're also going to try all the magical grilled cheeses we're making today.
Plus, we're going to reveal my hack for everyone who's on the keto diet, who misses the ooey gooey goodness of grilled cheese, because there's a solution out there.
Stay with us.
Nobody's left us.
A betrayed wife secretly records her husband, then kills his girlfriend.
She took my husband's way.
Before killing herself.
All new Oz.
That's coming up tomorrow.
The Dish and Oz is back with a hot and new twist on the cheesy sandwiches you loved.
This grilled cheese...
It's magical!
Isn't it?
Really, really good.
Everything a grilled cheese is supposed to do.
It's crunchy on the outside.
I gotta hand it to you.
The herbs are fantastic.
What about that cauliflower?
How do you think about that?
So I'm so proud of you.
Rarely have I felt this way.
You can sneak this in your daughter's lunch.
Oh, there you go!
I'm gonna try that.
She does do sandwiches for lunch.
Okay.
Now, I promise you all a hack, because you can't eat this on a keto diet.
But years ago, I operated the president of Cyprus.
And he invited me back to Cyprus.
And they have a secret there.
Looks like a kidney.
It's called halloumi cheese.
Here's the thing.
You put this in the pan like this, and you heat it up.
Without losing its shape, it'll shrink a tiny bit.
But it becomes like the bread of a sandwich without being a sandwich.
So taste this.
It's chewy.
It's got all the things that bread would normally do for you.
You could probably put grilled cheese in between this.
Tastes like saganaki, doesn't it?
It's exactly very similar.
It's that kind of cheese that holds its form.
Yeah, but it's chewy.
It has that salty, but very salty.
Low fat.
We go crazy on this in our house.
It's halloumi.
Halloumi.
Yeah.
And actually, what I love is, you know, we tried it way back when, and I know I'd never heard of it before, and now it's all over.
It's in a lot of grocery stores.
You just look in the cheese section.
Easy to find.
I can make this, and I don't make very much besides boiling water.
All right.
That's a good one, Doc.
I like that one.
For the keto lovers out there.
There we go.
All right, so today is sandwich day here, and I have a little game, because you know I always bring the fun.
And the game, I'm calling it today, the state of the foodium.
Like the State of the Union?
Yes, come on.
Yes.
State of the Foodian.
Yes, State of the Foodian.
State of the Foodian.
Take it away.
Play along with me.
All right.
So here's how we play the game, ladies and gent.
I'm going to say the name of the region of the United States, and you have to tell me what they call the sandwich there.
The name they call the sandwich, right?
Oh, I love this sandwich.
Yes.
All right.
State of the Foodian.
That's why I got you.
All right.
New England is the first place.
What do you think they call their sandwich in New England?
You mean, like, you're talking about, like, a sub or a hoagie?
Where's the grinder?
Hoagie?
I heard it.
What did you say?
A grinder?
It is a grinder!
Yes!
She got it right!
She got it right!
I went to college in New England, so I would have gotten that one right.
There we go.
Okay.
I wonder where that name comes from, though.
It's New England.
It's probably 400 years old.
We don't know.
Probably so.
Alright, so the next one is Philadelphia.
We grew up there.
We don't get to say it.
What do they call their sandwich in Philadelphia, people?
Come on, you know this.
We hug each other in Philadelphia.
What is it called?
Hoagie!
Hoagie!
All right.
You all have to get this right.
All of us have to get this right.
What do they call it in New York?
What do they call their sandwich in New York?
A sub.
But it depends though.
Westchester, we call it a wedge.
A wedge?
A wedge?
And that's not right.
They call it a hero.
A hero.
Everyone comes to New York.
They have every name for it.
Yes, I'm a hero.
Okay, the next one.
The Gulf Coast.
What do they call a sandwich at the Gulf Coast?
A po'boy?
What is that?
A po'boy?
She's got it right!
That was right!
That was right!
I just know that a shrimp po'boy and I go way back, so I'm taking it there.
She's got it.
She's a sandwich genius, y'all.
All right, so the last one is in Boston.
Wait, wait, come on.
We got to know.
Does anyone know it?
Anyone call it out?
Anybody out there?
Bostonian?
Where am I? Nobody from Boston?
You can't?
Nothing?
Nobody.
All right.
You went to college there.
I know, but we called it a grinder.
Well, here's the thing.
It depends on which neighborhood that you're from or where you live, what you call a sandwich.
Certain parts of Boston, they call it a Spucky.
Anybody got that?
Spucky.
Yes.
I think you made that up.
I would never make that up.
Spucky.
Yeah.
Well, shout out to my people from Boston.
Back me up.
If you're from that neighborhood, it's a Spucky.
Please send us a note if it's really called a Spucky.
I think she made that up.
Please.
Oh, gosh.
Come on.
She's from the South.
She made that up.
Everyone, I hope you enjoyed your little cheese.
Try some of these recipes.
We'll see you next time.
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