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We have developed speed, but we have shut ourselves in.
Machinery that gives abundance has left us in want.
We think too much and feel too little.
More than machinery.
We need humanity.
We know the air is unfit to breathe and our food is unfit to eat.
As if that's the way it's supposed to be.
We know things are bad, worse than bad.
They're crazy.
You've got to say, I'm a human being!
God damn it.
My life has value.
You have meddled with the primal forces of nature.
Don't give yourselves to brutes.
Men who despise you, enslave you, who regiment your lives, tell you what to do, what to think, or what to feel, who drill you, diet you, treat you like cattle, use you as cannon fodder.
Don't give yourselves to these unnatural men!
Machine men with machine minds and machine hearts!
Ha ha!
It's showtime!
It's time to buckle up for making sense of the madness.
And who loves you and who do you love?
Hey, everybody, Jason Burmese here, and we often highlight transhumanism on this program and artificial intelligence in its most real sense.
Let Whole Brains Grow00:15:20
In other words, the different types of quote-unquote AI, what is it able to produce?
When we are talking about chatbots, how it is really about narrative management, and you have to set all these different parameters around it to get anywhere near the truth, or sometimes you just have to keep pressing it on the issues, showing it examples, and then it will placate you.
But in essence, it becomes what is really a reflection of what you yourself is willing to accept.
Now, when we talk about artificial intelligence and we talk about transhumanism, obviously the two are inexplicably linked.
But right now, as we go from AI to artificial general intelligence and more and more of these quote-unquote bot-like beings that are trying to provide really an imitation of life, we have to keep highlighting technologies like quote-unquote organoids.
Now, what is an organoid?
Well, an organoid is essentially an artificially grown brain of some type.
And they vary in differences, but what we're really talking about is bioengineering, nanotechnology, and the coupling of that technology, what scientists will call wet electronics.
They'll say we're wet electronics, people like Dennis Bushnell forever, for example, with traditional electronics.
And we've done that episode where we talked about the composer who used his brain waves to create sounds and then later on, post-humanistly had his organoids taken from stem cells because it's not like these things are completely artificially created.
We've never been able as human beings to create consciousness to create life from nothing, right?
It's a huge argument when you talk about that biogenesis and this kind of species to species evolution, macroevolution theory.
It doesn't really hold up.
I'm just going to say that.
Adaptation holds up.
Mutation holds up.
You know, species evolving separately because of their environments like that, you know, adaptation, that's a real thing.
And so what's happening right now is that they are taking stem cells and they are creating different types of organoids and some of which that will be incorporated into AGIs.
Now, I often wonder whether or not a lot of this is simply hocum to get human beings to adapt to the idea.
Well, they're growing brains artificially.
And those brains, those artificial, they're almost human.
I mean, they're part human.
Again, it's transhumanism in the reverse sense to strip us of our humanity, of our identity.
Whether or not this type of technology, especially when incorporated into traditional electronics and machinery, is viable or not.
I don't think that's the point.
But maybe it is.
Maybe it is.
Maybe the reverse cyborgs that they're creating are the next big thing.
We're going to get into all of it right here.
Thumbs it up, subscribe, share, ring, ring, ring that bell, get all the notifications.
Please check out all the documentary films, Loose Change, Final Cut, and Fabled Enemies on 9-11, Invisible Empire, a New World Order to 5, and Shade the Motion Picture for my larger scale stuff.
And remember, I can't do it without you.
Let me say it again.
I cannot do it without you.
There are no paychecks.
I want to continue down these paths.
I want to continue going over Johns Hopkins University papers and things that you're not seeing in the vast majority of the alternative media.
When they're talking about AI, it's always summoning the demon or the Antichrist.
We want to show you more tangible stuff.
So I want to thank everybody who has donated.
Thank you, sir.
You are my go-to on transhumanism, AI 9-11, and everything else.
Thanks so much.
No, thank you.
And thank everybody who has supported the broadcast.
All right, let's get into it.
Scientists grew a tiny brain that fires like a 40-day old fetus, mimicking multiple parts of the brain.
This miniature mind could help scientists investigate a variety of neuropsychiatric disorders.
Now, let me just say this.
I'm not a Luddite.
I want technology to empower humanity, but I see how traditional psychology has treated human beings and what they have treated it with, and it is criminal.
It is criminal.
My God.
What favors have we done people?
In fact, it seems to be more about mind control and disruption than anything else than solving the issue.
So, you know, again, color me skeptical.
In recent years, organoids, self-assembling cells developed from stem cells, have provided scientists ways to investigate diseases and disorders in labs without the need for animal models or donated human organs.
Now, again, I'm all for technologies that give us more insights, that empower humanity.
But I often wonder if that's what this is.
So, this is the actual John Hopkins site.
We're going to read the whole thing because it's pretty short, but it's also dense enough where I'm going to let you guys decide.
I'm not going to pretend like I'm the authoritative figure creating organoids at the John Hopkins lab.
I am not.
I am not indeed.
So, researchers have grown a novel whole brain organoid complete with neural tissues and rudimentary blood vessels, an advance that could usher in a new era of research into neuropsychiatric disorders such as autism, such as autism.
And by the way, we're going to show these organoid breakthroughs at the Cincinnati Children's Facility.
But I will say this: let's take a win.
I was going to do a separate video on it, but the mercury is out of the shots.
Thimerosol is out of the shots.
We'll see how long that takes to go into action, but that has now been announced by RFK Jr. and HHS.
So, I'm telling you right now, I'm not Mr. Negative.
And I posted that, and I see people starting talking about his Israel policies.
Guys, let's grow up.
Everything's not about Israel.
Everything is not about Gaza.
And believe me, that is an issue that we talk about that is very dangerous.
Especially when we're talking about Middle Eastern policy, when we're talking about really the military-industrial complex and its place within the Middle East, and how it not only involves Israel, the United States, but you have the Five Eyes group, all these different entities.
Okay?
Right now, when we're talking about the health of our society and especially the United States in general, that's a huge win.
It's a huge win.
It's a huge win.
And, you know, I didn't want to get off on a jag there, but they're sitting here and they're talking about disorders such as autism and how organoids are going to help them navigate that.
I think there's plenty of other things that, you know, could help us navigate that.
Just want to put that out there.
Keep hitting the wrong button.
We've made the next generation of brain organoids, says lead author Annie Cathuria, an assistant professor in John Hopkins University's Department of Biomedical Engineering, who studies brain development and neuropsychiatric disorders.
Most brain organoids that you see in papers are one brain region, like the cortex or the hindbrain or the midbrain.
We've grown a rudimentary whole brain organoid.
We call it the multi-region brain organoid.
The MRBO.
It's not a new boy band.
It's the MRBO.
It's not a new government agency.
It's the MRBO.
The research marks one of the first times scientists have been able to generate an organoid with tissues from each region of the brain connected and acting in concert.
Okay.
And it was published in Advanced Science.
Let's see.
Having a human cell-based model of the brain will open possibilities for studying schizophrenia, autism, and other neurological diseases that affect the whole brain.
Work that typically is conducted in animal models.
So they're moving to these artificially created humanoid substances and artificial intelligence, folks.
To generate a whole brain organoid, Katharia and members of her team first grew neural cells from the separate regions of the brain and rudimentary forms of blood vessels in separate lab dishes.
The researchers then stuck the individual parts together with sticky proteins that act as a biological super glue and allowed the tissues to form connections.
As the tissues began to grow together, they started producing electrical activity and responding as a network.
The multi-region mini-brain organoid retained a broad range of types of neuronal cells with characteristics resembling a brain in a 40-day-year-old human fetus.
Some 80% of the range of the type of cells normally seen at the age of human brain development was equally expressed in the laboratory-crafted miniaturized brains.
Much smaller compared to a real brain, weighing it at 6 million to 7 million neurons, compared to tens of billions in adult brains.
These organoids provide a unique platform on which a study whole brain to study whole brain development.
Now, I want to say this: think about this for a second.
They talk about this having characteristics resembling a 40-degree day-year-old human fetus.
They're always telling you that a fetus isn't human life, right?
And there's essentially no brain activity.
But here they're like, hey, there's some brain activity.
I'm just saying that, you know, we're constantly, constantly given two different, you know, non-cohesive explanations for things.
Oh, look how good we're doing these artificial brains.
Oh, you know, a brain of a 40-year-old doesn't really exist.
Again, just pointing that out.
Just something I think is interesting.
That's all.
Keep hitting the wrong button.
Not my finest hour, folks.
Let's continue.
The researchers also saw the creation of an early blood-brain barrier formation, a layer of cells that surround the brain and control with molecules which molecules can pass through.
We need to study models with human cells if you want to understand neurodevelopmental disorders and neuropsychiatric disorders.
But I can't ask a person to let me take a peek at their brain just to study autism, Catheria said.
Whole brain organoids let us watch disorder develop in real time, see if a treatment works, and even tailor therapies to individual patients.
And that's another thing that all this internet of things into the internet of bodies is supposedly telling us that we're going to have these individualistic therapies that are tailor-made for just us, just for our genetics.
Again, color me skeptical.
Let's finish this up.
And I hit the wrong damn button again.
I don't know why I keep hitting the wrong damn button.
Using whole brain organoids to test experimental drugs may also improve the rate of clinical trial success, researchers said.
Roughly 85 to 90% of drugs fail during phase one clinical trials.
For neuropsychiatric drugs, the fail rate is closer to 96%.
96%.
I mean, what does that tell you, folks?
90%.
And think about the stuff they put on the market.
This is because scientists predominantly study animal models during the early stages of drug development.
Whole brain organoids more closely resemble the natural development of the human brain and will likely make better test subjects.
I don't know.
Disease, and it just, it's the same line.
I don't even want to read the last paragraph.
This is extremely interesting as well.
This is that other aspect.
But before we get into that other aspect of organoids in conjunction with AGI and traditional electronics, as you can kind of see in the thumbnail, human brain organoids, credit, David Ballot, San Diego.
We're going to play this clip.
And again, they always talk about benevolence and, you know, we're going to solve things.
And I'm all for it.
I'm all for solving things.
But how much have we solved in my lifetime?
The dawn of a new era in medical science is upon us.
At Cincinnati Children's, an innovative journey begins, promising a revolution in the way we understand and treat illnesses.
I want to look forward.
And the only way to look forward is to see things no one's ever seen before.
And that's what this biology is allowing us to do.
Imagine a world where organ failure is not an end, but a new beginning, where regeneration and healing flow seamlessly from scientific discovery into the hearts of those who need it the most.
In the bustling labs of Cincinnati Children's, leading scientists are charting new territories.
New Era in Medical Science00:03:15
They are building upon a powerful breakthrough.
The development of organoids, miniature, lab-grown organs that mirror their full-sized counterparts.
We've been pioneering the organoid models that span across the entire human body.
So we have created human brain, human gastrointestinal tract, including esophagus, stomach, small and large intestine.
These organoids hold the key to not only visualizing disease like never before, but also to unlocking treatments that were once thought impossible.
So the promise of organoid research, it's enormous.
It's no longer a science fiction.
A few years back, we were talking about growing our own cells in the lab, building functional human tissues and functional human organs.
Right now, this is a reality and we are living it today.
The impact of this groundbreaking innovation goes far beyond organ transplantation.
Organoids offer an unprecedented opportunity to accelerate personalized medicine, identifying how a specific treatment can benefit an individual patient from autism to ALS, cancer to Parkinson's.
The word no doesn't exist in my vocabulary.
It's what's the next way to do that.
That's what philanthropy does.
It tells me not to accept no.
This exploration into organoids isn't just about groundbreaking science.
It's about heart and soul.
It's about the mother who can once again dream of watching her child play in the sunlight, free from pain.
It's about the father who can hope for a future where his child's health is not a lingering doubt, but a vibrant reality.
Cincinnati Children stands at the forefront of these possibilities, fueled by relentless commitment and visionary partnerships.
But this quest is more than a scientific endeavor.
It is deeply personal.
And it cannot succeed without the compassionate hearts of supporters like you.
Together, we can turn scientific possibilities into realities, rewriting the narrative for children and families around the globe.
Become a part of this extraordinary journey.
We do things that other people think are crazy that will never work.
And yet they give us insight that has led us to today.
With your help, we will cultivate breakthroughs in organoid research and medicine.
Because every child deserves the chance to dream, to play, and to live their best possible lives.
So, you know what I saw there?
I saw a lot of over-promising.
I saw them playing on the heartstrings of children in particular.
I saw them throw in the cancer word with autism and all these other things.
And boy, have they been promising to me and my generation they were going to get rid of cancer instead of exploding everywhere.
So, again, color me skeptical.
The Brunswick lab, we got all these different labs.
We got, I mean, organoids you're going to start hearing about, not just from Jason Burmes.
I promise.
Brunswick Lab looks perfectly normal.
Data Blob's Journey00:03:12
Perfectly normal masks and glove scientists are pulling petri dishes from fridges, lining up microscopes, and describing the workings of a dark blob splayed untidily on a microchip.
The blob.
The blob is anything but normal.
It is a mini-brain or a mini hippocampus to more accurately describe the cells.
See how this one is an individual part of the brain incorporated into traditional electronics, whereas the other one was a multitude.
And it's growing onto a tiny silicon chip.
Wiggling.
Gossamer threads spray outwards above dark map-like lines of circuitry as the organoid sends feelers outward into its tiny world.
What are they doing?
Great question.
They're extending.
That's the thing with biology.
It's beautiful.
It seeks out connections.
So it seeks out connection, and then you end up with these integrated circuits that we control.
We've got a paper under review now comparing the organoid intelligence pathway versus what we're calling bioengineered intelligence.
The interesting thing is that neurons show a huge variety of responses.
So figuring that out is part of sort of the algorithms of intelligence, if you will.
Kagan's company is one of a handful at the forefront to work to build a biological computer that can skip past the limitations of the OS, the zeros and ones that artificial intelligence is built on.
So you got quantum computing, you got traditional computing, they're incorporated into one another.
One doesn't work without the other.
And now they're trying to bioengineer these computers, telling you that it's going to make the AI better.
But what biological intelligence may be able to solve many of the problems currently facing artificial intelligence, the huge energy requirements and fundamentally different way of reasoning for a start, it also comes with a big ethical question we don't have answers to yet.
Oh, you think?
You think?
Biological computers' brains are undeniably more powerful than silicon ones.
Are they?
As demonstrated in 2021 by researchers from Hebrew University of Jerusalem, they showed that one cortical neuron has similar processing power to a multi-layer deep neural network, the foundation of deep learning models.
All that tells me is we're pretty awesome.
We're pretty awesome.
But the differences run deeper, right down to the way biological and artificial intelligence operates.
Casual reasoning in the neural root of tomorrow, dreaming, it's our brain's ability to think.
This leads to that.
It can be based on some data or no data, or even go against all data, wrote a neuroscientist turned English professor Angus Fletcher.
Wrapping Up Today's Discussion00:01:13
And he's right there.
Listen, just like we were talking about with Giordi Rose earlier this week and artificial intelligence, these things are different than us.
Large language models are not humans.
They're trying to blur that line.
They're trying to make these things ever more human-like because transhumanism is the next big step as more and more power is centralized.
Folks, I think that's where I'm going to wrap it up today.
I want you to thumbs it up, subscribe, share.
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I need you, need you, need you.
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As always, it is not about left or right.
Nothing in this show was Republican or Democrat.
Not a thing.
It's not liberal or conservative.
It's always right and wrong over here at Making Sense of the Madness.