Dec. 14, 2023 - Epoch Times
10:19
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| Two weeks ago, Japan became the first country in the world to approve a new type of self-amplifying mRNA vaccine, otherwise known as an SA mRNA vaccine. | |
| Specifically, a company called Meiji Seika Pharma that's based out in Tokyo, they released a statement on November the 28th announcing the fact that they've been given official government approval to manufacture and market a replicant vaccine, which is the first ever to use self-amplifying mRNA technology. | |
| Here is part of what their statement said. | |
| Quote, | |
| Now obviously, I'm sure that almost everyone watching this video right now has the very same question in their mind. | |
| What in the world is a self-amplifying mRNA vaccine? | |
| Well, to answer that question, Let's compare this new vaccine to the quote-unquote normal mRNA vaccines, like the ones from Pfizer and Moderna. | |
| Here's how the normal mRNA vaccines work. | |
| Whether it's Pfizer or Moderna, this is the basic outline. | |
| You have a strand of modified mRNA, which contains in it a sequence for making the spike protein of the SARS-CoV-2 virus. | |
| That's the part in red. | |
| And the strand of RNA is protected by a layer of lipid nanoparticles, which dissolves in the process of getting the RNA strand into the body's cells. | |
| Then once the RNA strand is delivered into the human cell, the cell's machinery takes it, it manufactures the spike protein that's encoded in the RNA, and that spike protein then leads ultimately to the immune response. | |
| Now of course, that's an extremely simplified version of how that process works. | |
| But that is generally how it works. | |
| That is how the typical mRNA vaccines that have been on the market for the past three years now, that's how they operate. | |
| However, these new self-amplifying mRNA vaccines, they take this process to another level by integrating the genes that are needed to replicate the RNA. Here's how that looks. | |
| The self-amplifying RNA vaccine contains two separate genes. | |
| First, there's the gene for the spike protein, that's the part in red, but then also, secondly, it contains the gene for a protein called replicase, which is what allows the RNA to self-replicate, that's the part in yellow. | |
| And so the way it works is that once this vaccine enters the human cell, the gene that's marked in yellow gets encoded by the body's cell into the protein called replicase. | |
| And that protein then allows for the vaccine's RNA to be copied over and over and over again. | |
| And as you can see, using this self-amplifying method, the end effect is that the cell now has significantly more of this RNA inside of it. | |
| This then leads to significantly more production of the spike protein, and then subsequently, in theory, more antibodies. | |
| In summary, here is how an article over in Nature magazine described the difference between the conventional mRNA vaccine and this new SA mRNA vaccine. | |
| Quote,"...conventional mRNA-based COVID shots consist mainly of the genetic instructions for a viral protein that are surrounded by regulatory sequences. | |
| A cell's machinery produces the protein for as long as these instructions persist and that protein, known as an antigen, stimulates an immune response." By contrast, saRNA jabs go a step further by integrating the genes needed for the replication and synthesis of the antigen-encoding RNA, effectively establishing a biological printing press for fabricating the vaccine inside cells. | |
| Now, in terms of the supposed benefits of using this new self-amplification technology, the researchers who developed it, they say that the main benefit is the fact that because the RNA portion of the vaccine copies itself over and over and over again, well, you don't need to inject as much RNA into a person's arm. | |
| And therefore, at least in theory, there should be fewer side effects. | |
| And indeed, the amount of substance injected into a person's arm is significantly less with this new method. | |
| For instance, in a recent study of the SA mRNA vaccine, each trial participant was given two doses, and each dose contained only 5 micrograms of RNA. You compare that to the Pfizer shot, which contained 30 micrograms per shot, and the Moderna shot, which contained 100 micrograms per shot. | |
| And so it's true. | |
| In terms of raw payload, the SA mRNA vaccine delivers significantly less RNA. In fact, here's how the rationale of the researchers behind this new vaccine was laid out in the pages of a Nature magazine article. | |
| People often think that the SA RNA vaccine platform is simply a variation on conventional mRNA shots. | |
| But in practice, it's really not. | |
| SA RNA is a totally different beast. | |
| Because of its virus-like nature, SA-RNA interacts with the immune system in distinctive ways that could prove beneficial across a range of disease scenarios. | |
| When it comes to preventing infections, for instance, its self-amplifying capabilities could enable the use of lower vaccine doses. | |
| The COVID self-amplifying RNA vaccine requires one-tenth to one-sixth as much vaccine per person as other RNA-based COVID-19 booster jabs. | |
| Reducing the amount of vaccine administered in each injection should result in lower production costs. | |
| And although the side effect profile of the COVID-SA mRNA vaccine seems comparable to that of a conventional mRNA shot, it is conceivable that the benefits of the platform's smaller doses will help to mitigate the severity of aches, fevers, chills, and other loathsome symptoms collectively known as reactogenicity. | |
| And so these researchers are claiming that by injecting less RNA into the arm, the person might, in theory, experience less side effect reactions. | |
| That's one supposed benefit. | |
| The second benefit that they claim this new vaccine to have is the fact that the self-amplifying method triggers higher levels of antibodies. | |
| which might actually circulate in the body for a longer period of time. | |
| Quote, Although, to be frank with you, reading through how this new technology works, well, there is one thing that I just do not understand. | |
| Because the claim here is that the benefits of this new SA mRNA vaccine is that for one, less RNA has to be injected into the person, and therefore there will be less overall side effects, and that secondly, more spike proteins will be encoded, leading to bigger and longer protection. | |
| However, over the last several years, I've read multiple studies, including this one here that's found on the American Heart Association's website, as well as this other one here found on the NIH website, showing that the spike protein is linked to many different problems, such as injury to the heart muscle, brain fog, general inflammation, among many, many other things. | |
| And so, after reading through how this new technology works, I'm personally a little unclear as to how they can claim that one benefit is less side effects, but at the same time, another benefit is the fact that it boosts the amount of spike protein in the body. | |
| I can't understand how those two work together. | |
| If anyone watching this is more dialed into the science, consider leaving a comment below. | |
| I'm sure that many people watching this episode will benefit greatly from your understanding. | |
| However, setting that part aside and getting back to what's happening over in Japan, well, this new technology has been given approval for manufacturing and marketing within the country for the treatment of COVID-19. | |
| Quote, Kostave is a vaccine against COVID-19 applying self-amplifying mRNA technology developed by Arcturus Therapeutics Incorporated, which is designed to self-amplify ones delivered into the cells, so that it generates a strong immune response and the potential for extended duration of protection while using lower doses of mRNA compared to the existing mRNA vaccines. | |
| Since its self-amplification is limited to over time, no safety issues have been identified. | |
| Meiji Seca Pharma is currently preparing for, and conducting clinical trials of, replicant mRNA vaccines against novel variants of COVID-19 virus and intends to commercialize them in 2024. | |
| And so, if you happen to be in the market for trying a brand new vaccine, well, the only thing between you and this new SA mRNA shot is a plane ticket to Japan. | |
| If you'd like to read more about how this new self-amplification technology works, as well as this entire statement from the company over in Japan, I'll throw all my research notes down into the description box below if you happen to be the type of person that likes to dig into the wheat. | |
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